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Re-arthroscopic Findings 18 Years After Osteochondral Autologous Transplantation for Cartilage Lesion in the Knee: A Case Report.
J Orthop Case Rep
January 2025
Department of Orthopedic Surgery, National Hospital Organization Kyoto Medical Center. 1-1 Fukakusa-Mukaihatacho, Fushimi Ward, Kyoto city, Kyoto Prefecture, 612-8555, Japan.
Introduction: Despite the good clinical outcomes of osteochondral autograft transplantation (OAT), reports of re-arthroscopic findings after OAT have been limited to short-term, and there are no reports of findings after long-term follow-up. This is the first report that describes re-arthroscopic findings long-term after OAT.
Case Report: A male patient underwent OAT on the lateral femoral condyle (LFC) of the knee and lateral meniscus (LM) repair at the age of 45.
Varus alignment of the hip and knee 2 years after anterior cruciate ligament injury is associated with medial tibiofemoral osteoarthritis 3 years later.
J Exp Orthop
January 2025
Department of Clinical Sciences Lund, Orthopaedics, Clinical and Molecular Osteoporosis Research Unit Faculty of Medicine Lund University Lund Sweden.
Purpose: To investigate if hip and knee alignment assessed 2 years after anterior cruciate ligament (ACL) injury is associated with compartment-specific radiographic knee osteoarthritis (OA) 3 years later.
Methods: An exploratory analysis was conducted in the knee ACL, nonsurgical versus surgical treatment (KANON) trial (ISRCTN84752559); 115 subjects with acute ACL injury were assessed at the 2-year follow-up; full-limb images of the injured leg were acquired, and the neck-shaft angle (NSA) and hip-knee-ankle angle (HKA) were measured. At the 5-year follow-up, weight-bearing tibiofemoral and patellofemoral radiographs were obtained.
The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain.
Osteoarthr Cartil Open
March 2025
Pain Centre Versus Arthritis and Academic Unit of Injury, Recovery and Inflammation Sciences, University of Nottingham, UK.
Objectives: Histological osteochondral characteristics of inflammation, fibrosis, vascularity, cartilage islands, vessels entering cartilage, thickened trabeculae and cysts are associated with bone marrow lesions (BMLs) in human knee osteoarthritis (OA). We identified and developed a method for scoring comparable pathology in two rat OA knee pain models.
Methods: Rats (n = 8-10 per group) were injected with monoiodoacetate (MIA) or saline, or underwent meniscal transection (MNX) or sham surgery.
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage.
Arthritis Res Ther
December 2024
Department of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Background: Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to OA pain pathogenesis. Notably, in rodents, macrophages in the DRG are associated with onset of persistent OA pain.
View Article and Find Full Text PDFAnterior Cruciate Ligament Reconstruction in Patients Older Than 50 Years: A Descriptive Study With Minimum 10-Year Follow-up.
Orthop J Sports Med
December 2024
Institut Universitaire Locomoteur et du Sport (iULS), Hôpital Pasteur 2, Nice, France.
Background: Anterior cruciate ligament (ACL) reconstruction is increasingly being performed in patients >50 years old; however, the long-term outcomes are unclear.
Purpose: To analyze the functional results, osteoarthritic progression, reoperation rate, and failure rate at minimum 10-year follow-up in patients >50 years old who have undergone primary ACL reconstruction.
Study Design: Case series; Level of evidence, 4.
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