Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cpt1971121105 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Remimazolam for Sedation and Trachospray for Topicalization During Flexible Nasal Intubation in a Spontaneously Breathing Patient.
Cureus
January 2025
Anesthesiology and Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, NLD.
When a difficult airway is anticipated, awake tracheal intubation can be considered. Usually, low doses of sedatives are administered during this procedure for minimal sedation and anxiolysis, such as midazolam and remifentanil. The newly developed ultra-short-acting benzodiazepine remimazolam has a pharmacokinetic profile that is more suitable for titration during awake tracheal intubation than the long-acting midazolam.
View Article and Find Full Text PDFDosing optimisation of intravenous lidocaine in patients with class 1-3 obesity by population pharmacokinetic analysis.
Anaesthesia
January 2025
Department of Anaesthesia and Perioperative Medicine, The Royal Brisbane and Women's Hospital, Brisbane, Australia.
Article Synopsis
- The study focused on developing an optimized lidocaine dosing regimen for obese patients during surgery, highlighting the need for more effective pain management.
- Researchers gathered data from 30 patients, measuring plasma levels of lidocaine and its metabolites to create a pharmacokinetic model.
- The findings suggested that current dosing was often inadequate, but an adjusted regimen could improve the likelihood of reaching therapeutic drug concentrations.
Impact of Storage on In Vitro Permeation and Mucoadhesion Setup Experiments Using Swine Nasal Mucosa.
AAPS PharmSciTech
December 2024
Department of Biosciences, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, 901 Limeira Avenue, Bairro Areião, Piracicaba, Sao Paulo, 13414-903, Brazil.
Intranasal topical administration offers a promising route for local and systemic drug delivery, with in vitro permeation and mucoadhesion studies often using porcine models. However, the impact of storage on mucosal integrity after the procedure remains unaddressed. This study aimed to standardize the preparation process and evaluated whether storage of porcine nasal mucosa impairs its integrity and permeability for experimental comparisons.
View Article and Find Full Text PDFA development of a gelatin and sodium carboxymethyl cellulose hydrogel system for dual-release transdermal delivery of lidocaine hydrochloride.
Int J Biol Macromol
January 2025
Department of Polymer Engineering, Faculty of Engineering, South Tehran Branch, Islamic Azad University, Po. Box: 11365/4435, Tehran, Iran; Nanotechnology Research Centre, Tehran South Branch, Islamic Azad University, Tehran, 15847-43311, Iran.
This study introduces a dual-release transdermal drug delivery system using a hydrogel matrix of cross-linked gelatin and sodium carboxymethyl cellulose (NaCMC). Designed for immediate drug release from microneedles (MNs) and sustained release from microcapsules (MCs), this system utilizes lidocaine hydrochloride as the model drug. The fabrication process involved casting the hydrogel into MN molds, with MCs embedded in the backing layer, establishing a dual-release mechanism.
View Article and Find Full Text PDFDevelopment and application of a quantitative LC-MS/MS assay for the analysis of four dental local anesthetics in human plasma and breast milk.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Clinical Pharmacology Research Center, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China. Electronic address:
Local anesthetics (LAs: articaine, lidocaine, bupivacaine, and mepivacaine) are essential for dental pain management. However, there are concerns that the lipophilic LAs could cross into breast milk causing toxicity to the infant. Our objective was to establish a multi-analyte LC-MS/MS method for the concurrent quantification of local anesthetics (LAs) in human plasma and breast milk, clarifying the transfer of LAs from plasma to breast milk, thereby offering crucial data for the safe assessment of LAs during the nursing period.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!