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| http://dx.doi.org/10.1136/bmj.4.5779.103 | DOI Listing |
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European cancer mortality predictions for the year 2025 with focus on breast cancer.
Ann Oncol
February 2025
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Electronic address:
Background: We predicted the number of cancer deaths and rates for 2025 in the European Union (EU), its five most populous countries, and the UK, focusing on breast cancer.
Materials And Methods: We derived population data and death certificates for all cancers and major sites for the EU, France, Germany, Italy, Poland, Spain, and the UK since 1970, from the World Health Organization and United Nations databases. Estimates for 2025 were computed by linear regression on recent trends identified through Poisson joinpoint regression, considering the slope of the most recent trend segment.
The Role of Mitochondrial DNA Copy Number in Venous Thromboembolism: Insights from a 2-Sample Mendelian Randomization Study.
Ann Vasc Surg
April 2025
Department of Cardiology, Dongying People's Hospital (Dongying Hospital of Shandong Provincial Hospital Group), Dongying, China. Electronic address:
Background: Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial dysfunctions and has been associations with arterial cardiovascular diseases. However, the role of mtDNA-CN in venous cardiovascular disease was unclear.
View Article and Find Full Text PDFIatrogenesis is a recognised aspect of healthcare. But could kindness, a prized ingredient in such work, be implicated in some of the iatrogenic harm? In a recent paper, I noted how healthcare professionals and institutions that appear to value and vaunt kindness can, in practice, fall not just occasionally short, but often systemically so. Rather than insisting on these as aberrations, I wondered whether, our practice of kindness may, as with use of antibiotics or X-rays, have its own less considered but nonetheless harmful side effects.
View Article and Find Full Text PDFThe added value of home-uroflowmetry; Analysing an individuals' VV-Qmax curve and inflection point.
Urology
March 2025
Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Urology, Antwerp University Hospital, Drie Eikenstraat 655, 2650 Edegem, Belgium; Antwerp Surgical Training, Anatomy and Research Centre (ASTARC), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. Electronic address:
Objectives: To analyse individual VV-Qmax plots based on multiple home uroflowmetries and compare these with cross-sectional nomograms.
Methods: Healthy volunteers (16-69 years) without LUTS were asked to take a Minze Homeflow device home to register 25 uroflows. Participants reporting urinary tract disorders, malignancy or medication affecting bladder function were excluded.
Cloning, Expression, Characterization and in silico studies of L-asparaginase from Vibrio sp. (GBPx3).
Biochimie
March 2025
Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:
L-asparaginase is a critical therapeutic enzyme for treating acute lymphoblastic leukemia (ALL), a common childhood malignancy. In this study, the L-asparaginase coding sequence from halophilic Vibrio sp. (GBPx3) was cloned, expressed in Escherichia coli, and characterized.
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