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KCNJ15 inhibits chemical-induced lung carcinogenesis and progression through GNB1 mediated Hippo pathway.
Toxicology
December 2024
Department of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China. Electronic address:
Polycyclic aromatic hydrocarbons (PAHs) are important environmental carcinogens that can cause lung cancer. However, the underlying epigenetic mechanism during PAHs-induced lung carcinogenesis has remained largely unknown. Previously, we screened some novel epigenetic regulatory genes during 3-methylcholanthrene (3-MCA)-induced lung carcinogenesis, including the potassium inwardly rectifying channel subfamily J member 15 (KCNJ15) gene.
View Article and Find Full Text PDFPredicted no-effect concentration for eight PAHs and their ecological risks in seven major river systems of China.
Sci Total Environ
January 2024
School of Urban Planning and Design, Peking University Shenzhen Graduate School, Shenzhen 518055, China. Electronic address:
The initial step in the assessment of the ecological risk of pollutants is to determine the predicted no-effect concentration (PNEC). However, ecological risk assessments of eight carcinogenic polycyclic aromatic hydrocarbons (PAHs), including dimethylbenz[a]anthracene (DMBA), methylcholanthrene (MCA), benzo(a)anthracene (BaA), chrysene (CHR), benzo(b)fluoranthene (BbF), benzo(k)fluoranthene (BkF), benzo(a)pyrene (BaP), and dibenzo(a,h)anthracene (DBA), are rarely conducted due to the lack of their PNECs based on test data. In this study, quantitative structure-activity relationship (QSAR) models and interspecies correlation estimation (ICE) models were combined to predict the acute toxicity of these eight target PHAs.
View Article and Find Full Text PDFInduction of epithelial-mesenchymal transition in thyroid follicular cells is associated with cell adhesion alterations and low-dose hyper-radiosensitivity.
Tumour Biol
September 2023
Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S.K. Mazumdar Road, Timarpur, Delhi, India.
Article Synopsis
- * In this study, researchers looked at thyroid cells that changed during cancer development, examining how they reacted to low-dose radiation after going through EMT.
- * They found that one type of transformed cell showed increased sensitivity to low-dose radiation, while other types did not, suggesting that the EMT process may make cells more vulnerable to radiation damage.
Deciphering the roles of aryl hydrocarbon receptor (AHR) in regulating carcinogenesis.
Toxicology
August 2023
Faculty of Science and Engineering, University of Nottingham Malaysia, 43500 Semenyih, Selangor, Malaysia. Electronic address:
Aryl hydrocarbon receptor (AHR) is a ligand-dependent receptor that belongs to the superfamily of basic helix-loop-helix (bHLH) transcription factors. The activation of the canonical AHR signaling pathway is known to induce the expression of cytochrome P450 enzymes, facilitating the detoxification metabolism in the human body. Additionally, AHR could interact with various signaling pathways such as epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), hypoxia-inducible factor-1α (HIF-1α), nuclear factor ekappa B (NF-κβ), estrogen receptor (ER), and androgen receptor (AR) signaling pathways.
View Article and Find Full Text PDFDynamic cyp1a1 transcript responses in the caudal fin of coho salmon (Oncorhynchus kisutch) smolts to low sulfur marine diesel water accommodated fraction exposures and depuration.
Aquat Toxicol
March 2023
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8P 5C2, Canada. Electronic address:
Oil spills that occur in high traffic coastal environments can have profound consequences for the health of marine ecosystems and the commercial and social interests that are dependent upon these habitats. Given that the global reliance on marine fuels is not abating, it is imperative to develop sensitive and robust tools to monitor oil contamination and remediation in a timely manner. Such tools are increasingly important for ascertaining the immediate and long-term effects of oil contamination on species of interest and local habitats as water-soluble components of oils, such as polycyclic aromatic hydrocarbons (PAHs), can persist post-remediation.
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