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Pharmacologic Management of Heart Failure with Preserved Ejection Fraction (HFpEF) in Older Adults.
Drugs Aging
January 2025
Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, 420 East 70th St, New York, NY, LH-36510063, USA.
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug events.
View Article and Find Full Text PDFComparison of health-related quality of life in atopic dermatitis, hidradenitis suppurativa, pemphigus and psoriasis.
Arch Dermatol Res
January 2025
Institute of Social and Political Sciences, Corvinus University of Budapest, Budapest, Hungary.
This study aims to explore the measurement agreement between direct and indirect health utility measures in four chronic dermatological conditions (atopic dermatitis, hidradenitis suppurativa, pemphigus, psoriasis). Outpatients survey data collected between 2015 and 2021 were analysed. Health-related quality of life (HRQoL) outcome measures included time trade-off (TTO), EQ-5D-5L and Dermatology Life Quality Index (DLQI).
View Article and Find Full Text PDFThe Relationships Between Multidimensional Schizotypy and Metacognitive Beliefs.
Psychol Rep
January 2025
School of Psychology, Faculty of Society and Design, Bond University, Gold Coast, QLD, Australia.
There has been a recent surge in schizotypy and metacognition research. Metacognition is an umbrella term for higher-order thought processes. Here, we focussed on maladaptive metacognitive beliefs, which are beliefs related to one's thought processes and often play an important role in the preponderance of psychological disorders.
View Article and Find Full Text PDFEnhancing creative process engagement in university students: the mediating role of trust and empowerment and the moderating effect of proactive personality in humble teacher leadership.
BMC Psychol
January 2025
School of Public Administration and Policy, Dalian University of Technology, Linggong Road NO. 2, Ganjingzi District, Dalian, 116024, Liaoning, China.
This study examines the interplay between humble teacher leadership and student creative process engagement, grounded in Social Exchange Theory and Self-Determination Theory. Additionally, it analyzes the sequential mediating roles of student trust and psychological empowerment, as well as the moderating effect of proactive personality. Data were collected at three time points from 384 participants across Chinese universities and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM) with Smart PLS 4.
View Article and Find Full Text PDFOnchocerciasis is not a major cause of blindness in two endemic villages in Sierra Leone.
BMC Res Notes
January 2025
Helen Keller International, New York, USA.
Objective: Sierra Leone, a country where onchocerciasis is endemic in 14 of the 16 districts, was the focus of our investigation. Despite 17 rounds of annual ivermectin treatment since 2005, a report circulated by a local politician indicated an increase in cases of suspected onchocerciasis-related vision impairment in two villages (Mangobo and Petifu) in Tonkolili district. In response, the National Neglected Tropical Disease Program conducted a comprehensive investigation.
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