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Background: The Amyloid-Tau-Neurodegeneration (ATN) biomarker framework for Alzheimer's disease (AD) indicates binary (presence/absence) designations for each type of pathology, without regard for anatomical distribution. Neurodegeneration is designated as positive if atrophy or hypometabolism are found on imaging. However, Clifford Jack et al.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Douglas Mental Health University Institute, Montreal, QC, Canada.
White matter hyperintensities (WMHs) are frequently observed in ageing individuals, and have a higher prevalence in neurodegenerative disorders such as Alzheimer's disease. Ex-vivo assessments of the microstructural alterations within WMHs have reported heterogeneous tissue alterations, with demyelination, axonal loss, and inflammation presenting with various degrees of severity. There is a crucial need to better assess the severity of WMH microstructural alterations in vivo, in particular with the emergence of anti-amyloid immunotherapies and the associated risk of Amyloid Related Imaging Abnormalities (ARIAs) in individuals with comorbid vascular disease.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
National Institute on Aging/National Institutes of Health, Baltimore, MD, USA.
Background: Insulin Resistance (IR) is implicated in brain aging and Alzheimer's disease (AD) pathogenesis. Dietary changes may promote brain health in older adults with metabolic abnormalities. An extensive animal literature suggests pro-cognitive and beneficial systemic and brain effects of intermittent fasting (IF) that may mitigate AD risk.
View Article and Find Full Text PDFBackground: White matter hyperintensities (WMHs) are age-related radiological abnormalities indicative of small vessel disease. It is unclear if WMHs in different regions represent similar pathophysiology and etiology. Here, we developed a framework to estimate WMH pathophysiology in vivo, which allowed us to precisely characterize spatial patterns of WMH tissue alterations associated with four disorders.
View Article and Find Full Text PDFBackground: The extent to which pathological processes in aging and Alzheimer's disease (AD) relate to functional alterations in the medial temporal lobe (MTL)-dependent brain networks is poorly understood. Here, we examined the relationship between tau accumulation in the (trans)entorhinal cortex and functional connectivity (FC) in two MTL-affiliated brain networks - the Anterior-Temporal (AT) and Posterior-Medial (PM) - in normal agers, individuals with preclinical AD, and patients with symptomatic AD.
Method: In this cross-sectional study, we analyzed data from 125 individuals from the Penn ADRC (Table 1).
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