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Clinical efficacy and safety of Tinidazole combined with minocycline in treating peri-implantitis.
Am J Transl Res
December 2024
Department of Stomatology, Hongci Hospital Tangshan 063000, Hebei, China.
Objective: To evaluate the effects of tinidazole (TNZ) combined with minocycline (MINO) on therapeutic effectiveness, bone resorption, and inflammation in peri-implantitis (PI).
Methods: This retrospective study included 96 PI patients admitted between January 2023 and February 2024. Patients were divided into a control group (n = 46) treated with MINO and a research group (n = 50) treated with TNZ plus MINO.
Successful Treatment of Mycoplasma genitalium Urethritis With High-Dose Tinidazole.
Sex Transm Dis
February 2025
From the Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH.
A 30-year-old male patient with symptomatic Mycoplasma genitalium urethritis failed treatment with oral azithromycin, 2-stage doxycycline-moxifloxacin, and minocycline. Molecular testing confirmed the presence of macrolide resistance mutations. Treatment with oral tinidazole 2 g daily for 7 days resulted in clinical and microbiologic cure.
View Article and Find Full Text PDFLong-term management of refractory vaginal trichomoniasis following initial metronidazole treatment failure: A case series.
Jpn J Infect Dis
December 2024
Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.
Guidelines for sexually transmitted infections recommend oral metronidazole (MNZ) as the first-line treatment option for vaginal trichomoniasis; however, there have been cases of prolonged symptoms or recurrence after treatment. To consider appropriate treatment strategies for refractory vaginal trichomoniasis, we conducted a retrospective cohort study. We reviewed the medical records of patients who tested positive for Trichomonas vaginalis (T.
View Article and Find Full Text PDFValidation of a sensitive bioanalytical method for metronidazole extraction from human plasma.
J Pharm Biomed Anal Open
June 2024
Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa College of Pharmacy, Iowa City, IA 52242, USA.
Metronidazole (MTZ) is a broad-spectrum antibiotic with numerous routes of administration, including topical. Topical application of MTZ gel or cream results in very low systemic absorption, resulting in the need for a sensitive extraction method to quantify plasma concentrations. Currently published methods are not suitable for analysis of plasma concentrations after topical application, as undetectable MTZ concentrations commonly occur.
View Article and Find Full Text PDFEfficacy and safety of different antibiotic treatment versus surgical treatment for acute appendicitis: A network meta-analysis.
World J Surg
December 2024
Emergency Department, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, China.
Objective: This systematic review and network meta-analysis compared various antibiotic treatments with surgical treatment for acute appendicitis.
Methods: We searched PubMed, Embase, Cochrane Library, and Wanfang databases for randomized controlled trials (RCTs) that met the prespecified inclusion criteria up to July 2023. The interventions included various antibiotics and surgery.
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