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ORAL ADMINISTRATION OF CYANTRANILIPROLE TO WISTAR RATS DURING PREGNANCY AND LACTATION ALTERS MATERNAL BEHAVIOR AND HARMS THE FEMALE REPRODUCTIVE SYSTEM OF PUBERTAL AND ADULT OFFSPRING.
Food Chem Toxicol
January 2025
Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, Brazil. Electronic address:
Over the past years, global pesticide use has increased by 20%. New insecticidal molecules, like cyantraniliprole, aim to reduce side effects due to the high toxicity of pesticides and their harmful effects on health and the environment. Its mechanism involves binding to ryanodine receptors, causing rapid calcium ion release.
View Article and Find Full Text PDFEarly life stress and pubertal predictors of subsequent substance use in a national diverse sample of adolescents: Sex and substance type matter.
Drug Alcohol Depend
January 2025
Department of Internal Medicine, College of Medicine, Charles R. Drew University of Medicine and Science, 1731 E. 120th St, Los Angeles, CA 90059, USA. Electronic address:
Background: Early life stress (ELS) increases the risk of substance use disorder (SUD) in adulthood. The pathway from ELS to SUD is hypothesized to be influenced by sex. We examine the impact of ELS on adolescent first substance use, a common precursor to adult SUDs, and test for sex differences in the relationship between ELS and risk of first use of alcohol, nicotine, and marijuana.
View Article and Find Full Text PDFIdentification of puberty related miRNAs in the hypothalamus of female mice.
Mol Cell Endocrinol
January 2025
Department of Molecular Genetics, Function and Therapy, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. Electronic address:
Background And Aims: Puberty is a crucial developmental stage marked by the transition from childhood to adulthood, organized by complex hormonal signaling within the neuroendocrine system. The hypothalamus, a central region in this system, regulates pubertal functions through the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-releasing hormone (GnRH) neurons, essential in puberty control, release GnRH in a pulsatile manner, initiating the production of sex hormones.
View Article and Find Full Text PDFCross-trait multivariate GWAS confirms health implications of pubertal timing.
Nat Commun
January 2025
Laboratory of Molecular Translational Medicine, Center for Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Pubertal timing is highly variable and is associated with long-term health outcomes. Phenotypes associated with pubertal timing include age at menarche, age at voice break, age at first facial hair and growth spurt, and pubertal timing seems to have a shared genetic architecture between the sexes. However, puberty phenotypes have primarily been assessed separately, failing to account for shared genetics, which limits the reliability of the purported health implications.
View Article and Find Full Text PDFMelatonin secretion across puberty: A systematic review and meta-analysis.
Psychoneuroendocrinology
January 2025
Danish Center for Sleep Medicine, Rigshospitalet, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Background: Melatonin levels decrease with aging and substantially during puberty. Studies have presented distinct melatonin levels in patients with disorders related to their pubertal development compared to healthy controls. The discrepancy suggests that a decrease in melatonin concentrations seen during adolescence might be related to the physical, hormonal, and/or neuronal alterations that occur during the pubertal period.
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