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Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Patients with acquired immunodeficiency syndrome (AIDS) have an increased risk of infectious colitis. While individual cases of infectious colitis are not rare, co-infections involving multiple opportunistic organisms are uncommon. Here, we present an AIDS patient with concurrent opportunistic gastrointestinal infections resulting in symptomatic infectious colitis.
View Article and Find Full Text PDFAn occurrence of intestinal histoplasmosis in a goat flock.
Iran J Vet Res
January 2023
Department of Veterinary Pathology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Orathanadu, Thanjavur, Tamil Nadu, India.
Background: The paper describes the first documentary evidence of intestinal histoplasmosis in Indian goats.
Case Description: A goat flock in delta region of Tamil Nadu with a report of mortality of eight animals with the history of inappetence, constipation, tenesmus and hematochezia. Three goat carcasses were presented for necropsy.
Colitis and Intestinal Granulomas in Acquired Immunodeficiency Syndrome.
Clin J Gastroenterol
August 2022
Division of Gastroenterology-Hepatology, Department of Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA.
Granulomas consist of focal collections of immune cells that forms as a result of chronic inflammation. They can be formed in different organs and are considered the hallmark for several inflammatory and infectious diseases. The presence of granulomas in the mucosal biopsies of the gastrointestinal (GI) tract of immunocompetent patients, along with histological features of chronicity, confirms the diagnosis of Crohn's disease (CD) in the majority of cases.
View Article and Find Full Text PDFP069 The Unrelenting Ulcer.
Am J Gastroenterol
December 2021
Penn State Hershey Medical Center, Hershey, Pennsylvania, United States.
Inflammatory Bowel Disease (IBD) is becoming more common in an increasingly diverse population. Exposure history is important, especially when prescribing immunosuppressive therapy. We present a case of suspected disseminated histoplasmosis in a gentleman with longstanding Ulcerative Colitis (UC) on anti-TNF with an atypical, large, non-healing duodenal ulcer.
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