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A new hypothesis to explain disease dominance.
Trends Genet
January 2025
Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Hessen, 61231, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Hessen, 61231, Germany; Excellence Cluster Cardio-Pulmonary Institute (CPI), Bad Nauheim, Frankfurt, Giessen, Germany. Electronic address:
The onset and progression of dominant diseases are thought to result from haploinsufficiency or dominant negative effects. Here, we propose transcriptional adaptation (TA), a newly identified response to mRNA decay, as an additional cause of some dominant diseases. TA modulates the expression of so-called adapting genes, likely via mRNA decay products, resulting in genetic compensation or a worsening of the phenotype.
View Article and Find Full Text PDFExploring the effects of gut microbiota on cholangiocarcinoma progression by patient-derived organoids.
J Transl Med
January 2025
Department of Psychiatry and Psychotherapy, University Medical Center Mainz, 55131, Mainz, Germany.
Background: Recent research indicates a role of gut microbiota in development and progression of life-threatening diseases such as cancer. Carcinomas of the biliary ducts, the so-called cholangiocarcinomas, are known for their aggressive tumor biology, implying poor prognosis of affected patients. An impact of the gut microbiota on cholangiocarcinoma development and progression is plausible due to the enterohepatic circulation and is therefore the subject of scientific debate, however evidence is still lacking.
View Article and Find Full Text PDFAntimatter in astronomy and cosmology: the early history.
Ann Sci
January 2025
Niels Bohr Institute, Copenhagen University, Copenhagen, Denmark.
So-called antimatter in the form of elementary particles such as positive electrons (antielectrons alias positrons) and negative protons (antiprotons) has for long been investigated by physicists. However, atoms or molecules of this exotic kind are conspicuously absent from nature. Since antimatter is believed to be symmetric with ordinary matter, the flagrant asymmetry constitutes a problem that still worries physicists and cosmologists.
View Article and Find Full Text PDFTop-Down versus Bottom-Up Approaches for σ-Functionals Based on the Approximate Exchange Kernel.
J Phys Chem A
January 2025
Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, D-81377 Munich, Germany.
Recently, we investigated a number of so-called σ- and τ-functionals based on the adiabatic-connection fluctuation-dissipation theorem (ACFDT); particularly, extensions of the random phase approximation (RPA) with inclusion of an exchange kernel in the form of an antisymmetrized Hartree kernel. One of these functionals, based upon the approximate exchange kernel (AXK) of Bates and Furche, leads to a nonlinear contribution of the spline function used within σ-functionals, which we previously avoided through the introduction of a simplified "top-down" approach in which the σ-functional modification is inserted a posteriori following the analytic coupling strength integration within the framework of the ACFDT and which was shown to provide excellent performance for the GMTKN55 database when using hybrid PBE0 reference orbitals. In this work, we examine the analytic "bottom-up" approach in which the spline function is inserted a priori, i.
View Article and Find Full Text PDFCross-layer latency analysis for 5G NR in V2X communications.
PLoS One
January 2025
CICESE, Ensenada, Baja California, Mexico.
The 5G network was developed to push the capabilities of wireless networks to previously unseen performance limits, e.g., transmission rates of several gigabits per second, latency of less than a millisecond, and millions of devices connected at the same time.
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