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Exploring habenular structural connectivity in Parkinson's disease: insights from 7 T MRI study.
J Neurol
December 2024
School for Mental Health and Neurosciences, Maastricht University, Maastricht, The Netherlands.
Background: PD is marked by both motor and non-motor symptoms, with its pathophysiology involving many neural pathways and brain regions beyond the dopaminergic system. While mainly gray matter changes have been noted, white matter changes also exist in PD. Habenula, known for its role in reward processing, mood regulation, motor functions, and cognition, is of interest due to its connection to mood disorders in PD.
View Article and Find Full Text PDFSubstantial projections from the lateral division of the lateral habenula to the dorsal raphe nucleus and from the lateral habenula to the contralateral ventral tegmental area.
Heliyon
November 2024
Department of Anatomy, Faculty of Medicine, University of Toyama, Japan.
The lateral habenular nucleus (LHb) projects to the dorsal raphe nucleus (DRN) and ventral tegmental area (VTA). Prior studies have reported that the medial division of the LHb (LHb-m) mainly projects to the DRN, while the LHb mainly projects to the ipsilateral VTA; however, due to only a few studies of projection ratio analysis, the degree of projection of minor and major pathways remains unclear, and the potential significance of minor pathways may be overlooked. After injecting the retrograde tracer into the mice DRN, the proportion of labeled neurons was 63.
View Article and Find Full Text PDFChronic unpredictable stress during adolescence exerts sex-specific effects on depressive-like behavior and neural activation triggered by tail suspension test.
Behav Brain Res
February 2025
Department of Pediatrics, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, China. Electronic address:
Article Synopsis
- Chronic unpredictable stress (CUS) during adolescence alters neuronal excitability in specific brain regions, which could lead to negative behaviors, particularly depressive symptoms in male mice.
- The study evaluated the effects of 12 days of CUS on anxiety and depression behaviors and analyzed neuronal activation using c-Fos expression before and after a tail suspension test (TST).
- Findings showed that CUS primarily impacted regions like the infralimbic cortex and the bed nucleus of the stria terminalis, revealing sex-specific differences in neuronal responses and laying groundwork for understanding mood disorders stemming from adolescent stress.
Early brain neuroinflammatory and metabolic changes identified by dual tracer microPET imaging in mice with acute liver injury.
bioRxiv
September 2024
The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Background: Acute liver injury (ALI) that progresses into acute liver failure (ALF) is a life-threatening condition with an increasing incidence and associated costs. Acetaminophen (N-acetyl-p-aminophenol, APAP) overdosing is among the leading causes of ALI and ALF in the Northern Hemisphere. Brain dysfunction defined as is one of the main diagnostic criteria for ALF.
View Article and Find Full Text PDFAtypical Course of the Habenulo-Interpeduncular Tract in Chick Embryos.
J Comp Neurol
July 2024
Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia, Spain.
Classical studies of the avian diencephalon hardly mention the habenulo-interpeduncular tract (a.k.a.
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