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Simultaneous determination of busulfan, fludarabine, phenytoin, and posaconazole in plasma from patients undergoing hematopoietic stem cell transplantation.
J Pharm Biomed Anal
January 2025
Department of Pharmacy, Hebei Children's Hospital, Shijiazhuang, Hebei 050031, China. Electronic address:
A simple, fast, sample-saving, and sensitive liquid chromatography-tandem mass spectrometry method was established with a linear range adjusted by in-source collision-induced dissociation. Notably, this could simultaneously determine busulfan, fludarabine, phenytoin, and posaconazole in plasma from children, each having unique physical and chemical properties. The procedure necessitated only 20 μL of plasma and involved a simple protein precipitation process.
View Article and Find Full Text PDFMultidimensional library for the improved identification of per- and polyfluoroalkyl substances (PFAS).
Sci Data
January 2025
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
As the occurrence of human diseases and conditions increase, questions continue to arise about their linkages to chemical exposure, especially for per-and polyfluoroalkyl substances (PFAS). Currently, many chemicals of concern have limited experimental information available for their use in analytical assessments. Here, we aim to increase this knowledge by providing the scientific community with multidimensional characteristics for 175 PFAS and their resulting 281 ion types.
View Article and Find Full Text PDFPhytochemical composition, antioxidant and antimicrobial activities of Delile ex Godr flowers extracts.
Nat Prod Res
January 2025
Laboratory of Organic Chemistry LR17-ES08 (Natural Substances Team), Faculty of Sciences of Sfax, University of Sfax, Sfax, Tunisia.
The phytochemical profile of various plant species reveals that some compounds possess notable antioxidant and antimicrobial properties. In this study we investigated for the first time, the antioxidant activity (FRAP, DPPH and TAC), total phenolic contents and total flavonoid contents of Delile ex Godr flowers extracts (-hexane, ethyl acetate and methanol) as well as their antimicrobial activity. The results obtained showed that the methanol extract contained the highest content of total phenolics (346.
View Article and Find Full Text PDFThe Effect of Drinking Ionized Water on the Productive Performance, Physiological Status, and Carcass Characteristics of Broiler Chicks.
Animals (Basel)
January 2025
Poultry Production Department, Faculty of Agriculture, Alexandria University, Alexandria 21545, Egypt.
Water treatment technologies have received great attention recently, as water is the most important nutritional element, and animals consume it daily in larger quantities than those of food. The ideal water treatment affects the chemical composition and physical properties of water, having a significant positive impact on the animal's physiology, productivity, and welfare. Studies conducted on water ionization devices for broiler chickens remain limited; therefore, this study was planned to investigate the effect of ionized drinking water on the productive performance, physiological status, and carcass characteristics of broiler chicks.
View Article and Find Full Text PDFBranched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering.
Nat Commun
January 2025
Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Lipid nanoparticles (LNPs) are the preeminent non-viral drug delivery vehicle for mRNA-based therapies. Immense effort has been placed on optimizing the ionizable lipid (IL) structure, which contains an amine core conjugated to lipid tails, as small molecular adjustments can result in substantial changes in the overall efficacy of the resulting LNPs. However, despite some advancements, a major barrier for LNP delivery is endosomal escape.
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