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Subanesthetic Ketamine Ameliorates Activity-Based Anorexia of Adult Mice.
Synapse
January 2025
Center for Neural Science, New York University, New York, New York, USA.
Objective: Anorexia nervosa (AN) is an eating disorder with the second highest mortality of all mental illnesses and high relapse rate, especially among adult females, yet with no accepted pharmacotherapy. A small number of studies have reported that adult females who struggled with severe and relapsing AN experienced sustained remission of the illness following ketamine infusions. Two other reports showed that 30 mg/kg IP ketamine can reduce vulnerability of adolescent mice to activity-based anorexia (ABA), an animal model of AN.
View Article and Find Full Text PDFRandomized Trial of the Four Supports Intervention for Surrogate Decision Makers in Intensive Care Units.
Am J Respir Crit Care Med
November 2024
University of Pittsburgh Department of Medicine, Pittsburgh, Pennsylvania, United States;
Rationale: Individuals acting as surrogate decision-makers for critically ill patients frequently struggle in this role and experience high levels of long-term psychological distress. Prior interventions designed solely to improve information sharing between clinicians and family members have been ineffective.
Objectives: To examine the impact of a multicomponent family support intervention on patient and family outcomes Methods: Patient-level randomized clinical trial at 6 intensive care units (ICUs) in a healthcare system in Pennsylvania.
Navigating life with single-ventricle CHD: psychosocial needs across adulthood.
Cardiol Young
November 2024
Texas Center for Pediatric and Congenital Heart Disease, UT Health Austin and Dell Children's Medical Center, Austin, TX, USA.
Objective: The population of adults with single-ventricle congenital heart disease (CHD) is growing. This study explores their lived experiences through an adult developmental psychology framework.
Methods: Individuals aged 18 and older with single-ventricle CHD participated in Experience Group sessions and 1:1 interviews.
Anticipatory postural adjustment deficits in children with developmental coordination disorder during a self-induced prehension task while standing on one leg.
Sci Rep
November 2024
Division of Physiotherapy, Department of Health and Rehabilitation Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Article Synopsis
- Effective postural control is crucial for developing motor skills, but anticipatory control in children with Developmental Coordination Disorder (DCD) is not well understood, especially during complex tasks like the Can Placement Task (CPT).
- The study involved 23 children with DCD and 30 typically developing (TD) peers aged 9-12, observing their movements while balancing on one leg and repositioning a can, and measuring their center of pressure (COP) with force platforms.
- Results showed that children with DCD had a greater range of COP movement, higher velocity before movement initiation, and relied more on external support, indicating impaired dynamic posture control and highlighting the need for more trials to complete the task compared
The concept of "control" in people with epilepsy: A qualitative study.
Epilepsy Behav
December 2024
Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, 630 W. 168(th) St, New York, NY 10032, USA; Department of Epidemiology, Columbia University Mailman School of Public Health, 722 W. 168(th) St., New York, NY 10032, USA; Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, 630 W. 168(th) St., 10032 New York, NY, USA; Division of Translational Epidemiology and Mental Health Equity, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. Electronic address:
Article Synopsis
- The paper investigates how individuals with epilepsy define and experience "control" regarding their condition, particularly focusing on seizure management and psychosocial effects.
- It analyzes interviews with 64 adults living with epilepsy, highlighting that their experiences of illness intrusiveness extend beyond just the frequency and severity of seizures.
- The findings reveal that anxiety and social challenges significantly affect the quality of life for people with epilepsy, suggesting that future care should adopt a holistic approach to improve their overall well-being and perceived control.
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