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The anti ulcerogenic effect of sildenafil and moringa on ulcers in rats.
Tissue Cell
December 2024
Department of Pharmacology, College of Medicine,University of Baghdad, Iraq; Department of Pharmacology, College of Medicine, University of Baghdad, Iraq. Electronic address:
Article Synopsis
- Moringa and Sildenafil oleifera (MO) may protect against gastric ulcers caused by medication in rats.
- The study tested various groups of rats with one group receiving the ulcer-inducing drug indomethacin, and some receiving the protective effects of either Sildenafil, Moringa, or both beforehand.
- Results showed that Sildenafil and Moringa effectively reduced ulcer severity and inflammation markers, indicating their potential as gastroprotective agents.
Trends in Proton Pump Inhibitor Use in Sweden by Sex and Age: A Drug Utilisation Study.
Drug Saf
December 2024
Department of Women's and Children's Health, Karolinska Institutet, Tomtebodavägen 18A, 17177, Stockholm, Sweden.
Background: Proton pump inhibitors (PPIs) are among the most popular drugs worldwide. Yet, there are concerns on long-term safety and poor adherence to prescription guidelines. Off-label use in children and increasing maintenance use in older adults may be particularly worrisome.
View Article and Find Full Text PDFSpiro-fused indoline-quinazoline hybrids as smart bombs against TNF-α-mediated inflammation.
Int J Biol Macromol
December 2024
Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, 12622, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia St., Alexandria 21648, Egypt. Electronic address:
Inflammation is central to numerous diseases, highlighting the need for new anti-inflammatory agents. This study explores the potential of novel spirofused indoline-quinazoline hybrids (4a-p) as anti-inflammatory compounds, inspired by a spiroisatin analogue (VI) that showed modest TNF-α inhibition. We aimed to enhance activity by modifying the isatin scaffold: first, introducing N-alkylation (propyl, butyl, or isobutyl) to improve hydrophobic interactions within the TNF-α dimer active site; second, adding halogens (F, Cl, Br) at the 5-position to increase lipophilicity.
View Article and Find Full Text PDFSynthesis and elucidation of strained galactopyronose esters as selective cyclooxygenase-2 inhibitor: a comprehensive computational approach.
RSC Adv
September 2024
Bioorganic and Medicinal Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong Chittagong 4331 Bangladesh +880 1716 839689.
Cyclooxygenase-2 (COX-2) is critically implicated in various pathologies, including inflammation, cancer, disorders involving the nervous system, and multidrug resistance. In both academic and pharmaceutical research, the development of COX-2 selective drugs as anti-inflammatory and anti-tumor therapeutics is a key focus. Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) have ulcerogenic, gastrointestinal adverse effects, and myocardial infarction risk, which resulted in their limited applications.
View Article and Find Full Text PDFBergenin inhibits growth of human cervical cancer cells by decreasing Galectin-3 and MMP-9 expression.
Sci Rep
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Department of Medical Oncology (Lab.), Dr. BRAIRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
Cervical cancer is still the leading cause of cancer mortality worldwide even after introduction of vaccine against Human papillomavirus (HPV), due to low vaccine coverage, especially in the developing world. Cervical cancer is primarily treated by Chemo/Radiotherapy, depending on the disease stage, with Carboplatin/Cisplatin-based drug regime. These drugs being non-specific, target rapidly dividing cells, including normal cells, so safer options are needed for lower off-target toxicity.
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