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GIT1 is an untolerized autoantigen involved in immunologic disturbance of spermatogenesis.
Histochem Cell Biol
March 2022
Department of Anatomy, School of Medicine, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku, Tokyo, 160-8402, Japan.
Male haploid cells, spermatids and spermatozoa, that appear after the establishment of immune tolerance express novel cell surface and intracellular proteins that can be recognized as foreign antigens by the self-immune system. However, these germ cells do not normally evoke a pathological immune response. The immune-privileged micro-circumstance in testis involving the blood-testis-barrier formed by Sertoli cells protects these germ cells from autoimmune attack.
View Article and Find Full Text PDFHeat shock protein A4L is a potent autoantigen for testicular autoimmunity in mice.
J Reprod Immunol
June 2021
Department of Anatomy, School of Medicine, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan. Electronic address:
Experimental autoimmune orchitis (EAO) may be used as a model to investigate immunological infertility in men. Murine EAO is induced via immunization with auto-immunogenic antigens (AIAgs) from testicular germ cells (TGCs). CD4 + T cells play a crucial role in EAO induction.
View Article and Find Full Text PDFPreventive effect of D-psicose, one of rare ketohexoses, on di-(2-ethylhexyl) phthalate (DEHP)-induced testicular injury in rat.
Toxicol Lett
September 2007
Department of Hygiene and Public Health, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.
To investigate the preventive effects of d-psicose, one of rare ketohexoses, on di-(2-ethylhexyl) phthalate (DEHP)-induced testicular injury, prepubertal male Sprague-Dawley rats were exposed to DEHP via their diet or orally, while under treatment with d-psicose. The rats given a diet-containing 1% DEHP alone for 7-14 days showed severe testicular atrophy accompanied by aspermatogenesis. On the other hand, those given the diet plus 2% but not 1% d-psicose-supplemented water for 14 days did not develop testicular atrophy, and exhibited an almost complete spermatogenesis.
View Article and Find Full Text PDFSplenic cytokines in mice immunized with testicular germ cells.
Int J Androl
September 2008
Department of Internal Medicine, Tamashima Central Hospital, Okayama, Japan.
We previously established that two subcutaneous injections of viable syngeneic testicular germ cells (TGC) alone can induce CD4+ T cell-dependent experimental autoimmune orchitis (EAO) in mice. This model is histologically characterized by lymphocytic infiltration into the testes and the following aspermatogenesis. In the present study, we investigated the dynamics of splenic cytokines in EAO, using specific enzyme-linked immunosorbent assay.
View Article and Find Full Text PDFTissue microcircumstances for leukocytic infiltration into the testis and epididymis in mice.
J Reprod Immunol
October 2005
Department of Anatomy, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku, Tokyo 160-8402, Japan.
Spermatozoa do not appear in the seminiferous epithelium until puberty, when immune tolerance has already been established. Therefore, they contain various autoimmunogenic materials which are recognized as foreign by the self immune system. However, the testis and epididymis are known as immunologically privileged organs.
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