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Article Synopsis
  • Porcelain gallbladder is a rare condition marked by calcification of the gallbladder wall, increasing the risk of gallbladder cancer and leading to high levels of the tumor marker CA19-9.
  • A case study presented a 60-year-old woman with abdominal pain and nausea, where imaging revealed porcelain gallbladder and common bile duct stones; her CA19-9 levels were extremely elevated after stone removal.
  • Post-surgery, histopathology showed no cancer but inflammation and calcification, and CA19-9 levels normalized, emphasizing that benign conditions can elevate CA19-9 and the importance of accurate diagnosis.
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Commonly referred to as a "porcelain gallbladder (PGB)," gallbladder calcification is usually asymptomatic. It is observed that chronic inflammation of the gallbladder can occur as a result of another underlying condition, specifically gallstone disease. In the past, there was a belief that PGB had a correlation with gallbladder cancer, with an incidence rate of 30%.

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[Prophylactic surgery for hepatic and biliary tumors].

Bull Cancer

June 2024

Service de chirurgie digestive, hépatobiliaire et endocrinienne, hôpital Cochin, AP-HP Centre, université Paris Cité, Paris, France. Electronic address:

Benign tumors of the liver and biliary tract are rare entities, and some of them require surgical management to prevent their malignant transformation. Tumors from the biliary tract with malignant potential are treated either by hepatic resection, for mucinous cystic neoplasm and ciliated hepatic foregut cysts, or by biliary resections, for biliary papillary neoplasm and type I and IV choledochal cysts. The pathologies requiring prophylactic cholecystectomy are polyps larger than 10 mm, porcelain gallbladder and pancreaticobiliary maljunction.

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Gallbladder carcinoma represents the most aggressive biliary tract cancer and the sixth most common gastrointestinal malignancy. The diagnosis is a challenging clinical task due to its clinical presentation, which is often non-specific, mimicking a heterogeneous group of diseases, as well as benign processes such as complicated cholecystitis, xanthogranulomatous cholecystitis, adenomyomatosis, porcelain gallbladder or metastasis to the gallbladder (most frequently derived from melanoma, renal cell carcinoma). Risk factors include gallstones, carcinogen exposure, porcelain gallbladder, typhoid carrier state, gallbladder polyps and abnormal pancreaticobiliary ductal junction.

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New trends in diagnosis and management of gallbladder carcinoma.

World J Gastrointest Oncol

January 2024

2 Propedeutic Department of Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece.

Gallbladder (GB) carcinoma, although relatively rare, is the most common biliary tree cholangiocarcinoma with aggressiveness and poor prognosis. It is closely associated with cholelithiasis and long-standing large (> 3 cm) gallstones in up to 90% of cases. The other main predisposing factors for GB carcinoma include molecular factors such as mutated genes, GB wall calcification (porcelain) or mainly mucosal microcalcifications, and GB polyps ≥ 1 cm in size.

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