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Difficult diagnosis: Disseminated gonorrheal infection manifesting as septic arthritis.
J Am Assoc Nurse Pract
August 2024
University of South Carolina College of Nursing, Columbia, South Carolina.
Disseminated gonococcal infection is the causative agent of approximately 0.6%-1.2% of septic arthritis cases in North America and Europe.
View Article and Find Full Text PDFA laboratory-based predictive pathway for the development of high-level resistance to corallopyronin A, an inhibitor of bacterial RNA polymerase.
Microbiol Spectr
June 2024
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Unlabelled: The continued emergence of strains that express resistance to multiple antibiotics, including the last drug for empiric monotherapy (ceftriaxone), necessitates the development of new treatment options to cure gonorrheal infections. Toward this goal, we recently reported that corallopyronin A (CorA), which targets the switch region of the β' subunit (RpoC) of bacterial DNA-dependent RNA polymerase (RNAP), has potent anti-gonococcal activity against a panel of multidrug-resistant clinical strains. Moreover, in that study, CorA could eliminate gonococcal infection of primary human epithelial cells and gonococci in a biofilm state.
View Article and Find Full Text PDFEffects of pubic hair grooming on women's sexual health: a systematic review and meta-analysis.
BMC Womens Health
March 2024
Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Background: Pubic hair grooming involves the partial or complete removal of pubic hair, and it is a common practice among men and women. Grooming is more prevalent in women, who employ various methods such as shaving, waxing and laser removal. However, it is associated with variable rates of post-grooming adverse outcomes including lacerations and sexually transmitted infections (STIs).
View Article and Find Full Text PDFGonorrheal and chlamydia yield for genital and extragenital testing in children evaluated for sexual abuse.
Child Abuse Negl
January 2024
The John P. and Kathrine G. McGovern Medical School, Department of Pediatrics, 6410 Fannin St Ste 1425, Houston, TX 77030, USA; Texas Forensic Nurse Examiners, 2990 Richmond Ste 180, Houston, TX 77098, USA. Electronic address:
Objective: Texas Forensic Nurse Examiners (TXFNE) performs routine testing of genital and non-genital sites for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), and further testing for other sexually transmitted pathogens. The current Centers for Disease Control and Prevention (CDC) guidelines recommend that testing be based primarily on patient history of type of sexual contact, patient age, community prevalence of sexually transmitted infections (STIs), perpetrator risk factors for STIs, and patient symptoms (Centers for Disease Control and Prevention, 2021). In this study, we were interested in determining whether our practice of testing all sites in all prepubertal patients presenting for sexual abuse for CT and NG resulted in identification of infections that would have been missed if testing had been limited to disclosed sites of sexual contact.
View Article and Find Full Text PDFPenicillin-resistant gonorrheal endocarditis presenting with large annular abscess and aortic valve destruction.
J Surg Case Rep
May 2023
Department of Cardiothoracic Surgery, Loma Linda University, Loma Linda, CA, USA.
Disseminated gonorrheal infections with cardiac involvement are rare, with fewer than 100 cases reported. The increasing prevalence of gonococcal infections and increasing antibiotic resistance represent a concerning challenge to public health. Here we report a case of antibiotic-resistant gonococcal endocarditis presenting with cardiogenic shock and discuss principles of diagnosis and treatment.
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