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Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun
December 2024
ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Department of Systems Biology for Medicine, Fudan University, Shanghai, China.
Thiamine and pyridoxine are essential B vitamins that serve as enzymatic cofactors in energy metabolism, protein and nucleic acid biosynthesis, and neurotransmitter production. In humans, thiamine transporters SLC19A2 and SLC19A3 primarily regulate cellular uptake of both vitamins. Genetic mutations in these transporters, which cause thiamine and pyridoxine deficiency, have been implicated in severe neurometabolic diseases.
View Article and Find Full Text PDFEfficacy of myrrh extract against Eimeria labbeana-like experimental infection in Columba livia domestica: in vivo study.
BMC Vet Res
December 2024
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Background: The Protozoan pathogen Eimeria is a significant issue in poultry production. Scientists are concerned with finding alternative strategies due to the spread of resistance against the commonly employed coccidiostats. This study examined how well myrrh extract (MyE) protected domesticated pigeons from an experimental Eimeria labbeana-like infection.
View Article and Find Full Text PDFCombined Administration of Metformin and Amprolium to Rats Affects Metabolism of Free Amino Acids in the Brain, Altering Behavior, and Heart Rate.
Biochemistry (Mosc)
October 2024
Belozersky Institute of Physicochemical Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
The risk of developing diabetes and cardiometabolic disorders is associated with increased levels of alpha-aminoadipic acid and disturbances in the metabolism of branched-chain amino acids. The side effects of the widely used antidiabetic drug metformin include impaired degradation of branched-chain amino acids and inhibition of intracellular thiamin transport. These effects may be interconnected, as thiamine deficiency impairs the functioning of thiamine diphosphate (ThDP)-dependent dehydrogenases of 2-oxo acids involved in amino acids degradation, while diabetes is often associated with perturbed thiamine status.
View Article and Find Full Text PDFPositive impact of dietary marine sulfated polysaccharides derived from macroalgae during a necrotic enteritis challenge.
Poult Sci
December 2024
Department of Poultry Science, University of Georgia, 120 D.W. Brooks Drive, Athens, GA 30602, USA. Electronic address:
Caused by the Gram-positive bacteria Clostridium perfringens, necrotic enteritis (NE) is an enteric disease with significant economic implications in broiler production. This study employed an experimental NE model involving co-infection with Eimeria maxima and C. perfringens to assess whether sulfate polysaccharides extracted from marine macroalgae could mitigate the adverse effects of NE in broilers.
View Article and Find Full Text PDFUse of Metallic Nanoparticles Against Eimeria-the Coccidiosis-Causing Agents: A Comprehensive Review.
Biol Trace Elem Res
October 2024
Department of Parasitology, University of Agriculture, Faisalabad, 38040, Pakistan.
Coccidiosis is a protozoan disease caused by Eimeria species and is a major threat to the poultry industry. Different anti-coccidial drugs (diclazuril, amprolium, halofuginone, ionophores, sulphaquinoxaline, clopidol, and ethopabate) and vaccines have been used for their control. Still, due to the development of resistance, their efficacy has been limited.
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