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Venous Thromboembolism Occurrence and Association with Gastrointestinal Disorders in Children with Cystic Fibrosis: An Analysis from the TriNetX Research Network Global Multicenter Real-World Dataset.
Semin Thromb Hemost
January 2025
Department of Pediatric Gastroenterology, University of South Florida Morsani College of Medicine, Tampa, Florida.
The purpose of this study is to (1) estimate and compare the prevalence of venous thromboembolism (VTE) in children (age 0 to ≤21) with versus without cystic fibrosis (CF); (2) investigate putative associations between specific gastrointestinal (GI) manifestations and the development of VTE among children with CF. This was a multicenter case-control analysis among patients aged 0 to ≤ 21 years between 2010 and 2020, using the TriNetX Research Network. Data queries included ICD-9/10 (International Classification of Diseases-9th/10th Revision) diagnosis codes.
View Article and Find Full Text PDFSuperficial Vein Thrombosis in an Asymptomatic Case of Cholangiocarcinoma with Recent History of COVID-19.
Life (Basel)
August 2024
Department of Internal Medicine and Gastroenterology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
The COVID-19 pandemic brought into prominence several emergent medical and surgical entities, but, also, it served as trigger and contributor for numerous apparently unrelated ailments such as arterial and venous thromboembolic complications. Additional risk factors for these thrombotic traits may be concurrent (known or unknown) malignancies, including at hepatic level. Among these, cholangiocarcinoma (CCA), a rare cancer of intra- and extra-hepatic biliary ducts, represents a very aggressive condition that typically associates local and distant advanced stages on first presentation requiring a prompt diagnosis and a stratified management.
View Article and Find Full Text PDFNecrotizing Pancreatitis After Bland Embolization of a Large Hepatic Hemangioma.
ACG Case Rep J
August 2024
Department of Gastroenterology and Hepatology, University of Texas at Medical Branch, Galveston, TX.
Article Synopsis
- Rare complications from this procedure may include serious conditions like pulmonary thromboembolism and necrotizing pancreatitis, the latter occurring in about 1.7% of cases.
- The causes of acute pancreatitis following liver embolization are not fully understood, but factors such as ischemic effects, toxic chemotherapy agents, and the amount of embolic material used might contribute.
Comorbidities and complications in adult and paediatric patients with pyruvate kinase deficiency: Analysis from the Peak Registry.
Br J Haematol
August 2024
Hematology Unit, Pathophysiology of Anemia Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Article Synopsis
- Pyruvate kinase (PK) deficiency is a rare genetic anemia linked to the PKLR gene, leading to various health issues; however, its full impact is not fully understood.* -
- The Peak Registry study analyzed 241 patients with PK deficiency, noting significant treatments like splenectomy (48.3%) and chelation therapy (50.5%), as well as common complications like iron overload and neonatal issues.* -
- Adult patients also face serious complications, such as bone health problems and pulmonary hypertension, highlighting the need for better awareness and management strategies among healthcare providers.*
Mesorectal thromboembolism with increased F-fluorodeoxyglucose uptake during positron emission tomography/computed tomography in a patient with non-small cell lung cancer.
J Surg Case Rep
July 2024
Division of Gastroenterological and Hepato-biliary-Pancreatic Surgery, Department of Surgery, Tohoku Medical and Pharmaceutical University, 1-15-1, Fukumuro, Sendai 983-8536, Miyagi, Japan.
This study presents a case of a 72-year-old man diagnosed with non-small cell lung cancer (cT4N0M0) referred to our hospital for possible surgical treatment of a solitary nodule detected in the mesorectum. The patient had received combined chemoradiotherapy and achieved a complete response 13 months before the presentation. On examination, the mesorectal nodule was incidentally detected during surveillance computed tomography, and the maximum standardized uptake value of the nodule was 10.
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