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GATA3-COMT1-Melatonin as Upstream Signaling of ABA Participated in Se-Enhanced Cold Tolerance by Regulate Iron Uptake and Distribution in Cucumis sativus L.
J Pineal Res
January 2025
Shenyang Agricultural University, Shenyang, Liaoning, China.
Selenium has the function of bio-stimulating hormone. However, the underlying physiological and molecular mechanisms of melatonin and abscisic acid as secondary messengers in improving cold tolerance by selenium are limited. This study investigated the effects of selenite on the cold stress of cucumber seedlings.
View Article and Find Full Text PDFPapillary Tumor of the Pineal Gland With Discordant FDG and FAPi Uptake.
Clin Nucl Med
January 2025
Department of Radiation Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
In recent years, 68Ga-FAP inhibitor has emerged as a possible substitute radiotracer to FDG for imaging of most of the tumors. Here, we report a 7-year-old girl diagnosed with recurrent papillary tumor of the pineal gland, presenting with complaints of headache and vomiting. 18F-FDG PET/CT revealed an FDG-avid enhancing lesion in the posterior part of the third ventricle.
View Article and Find Full Text PDFMelatonin Protects Against Cocaine-Induced Blood-Brain Barrier Dysfunction and Cognitive Impairment by Regulating miR-320a-Dependent GLUT1 Expression.
J Pineal Res
November 2024
Key Laboratory of Cell Biology and Key Laboratory of Medical Cell Biology, Department of Developmental Cell Biology, Ministry of Public Health and Ministry of Education, China Medical University, Shenyang, China.
Article Synopsis
- - Cocaine abuse disrupts the blood-brain barrier (BBB) by decreasing the expression of glucose transporter 1 (GLUT1) in brain cells, which leads to cognitive issues and increased BBB leakage.
- - The study reveals that cocaine elevates the level of miR-320a, which then reduces GLUT1 expression through the activation of the beta 2-adrenergic receptor (ADRB2).
- - Melatonin can help counteract cocaine-induced BBB disruption and cognitive impairment by boosting GLUT1 expression through a specific signaling pathway, suggesting it could be a potential treatment for cocaine-related problems.
Perfluorohexane sulfonate (PFHxS) is a ubiquitous perfluoroalkyl substance known for its environmental persistence and potential toxicity. This study investigated PFHxS's impact on zebrafish embryos, focusing on sensorimotor behavior, circadian rhythm disruption, and underlying molecular mechanisms. Under 24 hr dark incubations, PFHxS exposure induced concentration-dependent hyperactivity within larval photomotor response, characterized by the distinctive "O-bend" response, strong light-phase hyperactive movement and seizure-like movements.
View Article and Find Full Text PDFTime-of-Flight PET/CT Imaging of Ga-68-Dotatate: Normal Pattern, SUV Quantification, and Differences from Non-Time-of-Flight Imaging.
World J Nucl Med
June 2024
Nuclear Medicine, WRNMMC, Bethesda, Maryland, United States.
The biodistribution of gallium-68-dotatate (Ga-68-dotatate) and standardized uptake values (SUVs) using non-time-of-flight (TOF) positron emission tomography/computed tomography (PET/CT) cameras is well established. However, with the eventual retirement of older PET cameras and their replacement with newer, highly sensitive TOF PET/CT cameras, where SUV measurements are reportedly higher, updated knowledge of normal SUV range is needed and, to our knowledge, not previously reported. Our objectives are as follows: To establish normal Ga-68-dotatate TOF SUV database for common structures and to aid the visual detection of abnormalities objectively.
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