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Study on the detoxification and toxic effects of clam Ruditapes philippinarum exposed to 2,6-ditert-butyl-4-methylphenol (BHT): Oxidative stress, neurotoxicity, respiratory toxicity, and immunotoxicity.
Environ Res
January 2025
The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, 266003, PR China. Electronic address:
The bioaccumulation and toxic effects of synthetic phenolic antioxidants (SPAs) in aquatic ecosystems are of growing concern due to their widespread use and potential environmental persistence. This study investigated the detoxification and toxicological impacts of 2,6-ditert-butyl-4-methylphenol (BHT), a representative SPAs, on clams Ruditapes philippinarum using environmentally relevant exposure concentrations. BHT bioaccumulation was observed in both gills and digestive glands, with higher levels in the latter.
View Article and Find Full Text PDFExploring the neuroprotective benefits of phytochemicals extracted from indigenous edible fruits in Bangladesh.
Animal Model Exp Med
January 2025
Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
The increasing incidence of neurodegenerative diseases (NDs) and the constraints of existing treatment methods have spurred a keen interest in investigating alternative therapies. Medicinal plants, renowned for their long-standing use in traditional medicine, offer a hopeful avenue for discovering new neuroprotective agents. This study emphasizes the potential neuroprotective characteristics of edible fruit plants in Bangladesh, specifically focusing on their traditional folk medicine uses for neurological disorders.
View Article and Find Full Text PDFMALDI-MSI: A potential game changer in forensic sciences.
Forensic Sci Med Pathol
January 2025
School of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan.
Matrix-assisted laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI) is an analytical technique used for the spatial mapping of drugs, explosives, and organic samples, making it a game-changer in Forensic examination. It detects a wide range of biomolecules in their native state without specific tags, antibodies, labels, and dyes. This review aims to highlight the advancement of MALDI-MSI over time and its impact on Forensic Science due to high-resolution molecular imaging.
View Article and Find Full Text PDFDysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms.
NPJ Syst Biol Appl
January 2025
BIH Center for Regenerative Therapies (BCRT), Julius Wolff Institute (JWI), and Berlin Institute of Health (BIH); all Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), 10117, Berlin, Germany.
Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, and the clinical manifestations of COVID-19. Using a cross-sectional analysis of 244 individuals, we applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms.
View Article and Find Full Text PDF[Advances in pharmacological mechanism and toxicology of gambogic acid].
Zhongguo Zhong Yao Za Zhi
December 2024
Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu 610072,China Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China Chengdu 610072, China.
Gambogic acid, a caged xanthone compound derived from Garcinia, has been proven to be an important substance basis for the pharmacological effects of the plant. In recent years, it has received continuous attention due to its broad and significant pharmacological activities. Modern pharmacological investigations have demonstrated that gambogic acid endows various therapeutic effects such as anti-inflammatory, antioxidant, and anti-tumor activities, as well as benefits in retinopathy, organ protection, anti-microbial infection, bone protection, and neuropathic pain relief.
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