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Assessment of Correlation between Genetic Taste Perception Hormonal Fingerprint and Dental Caries Incidence in Schoolgoing Children: An Study.
Int J Clin Pediatr Dent
June 2024
Department of Pediatric and Preventive Dentistry, Dental College and Hospital, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
Background: Genetic predilection toward sweeter cariogenic foods mediated by the gene, tested by phenylthiourea [phenylthiocarbamide (PTC)] compounds. Some individuals find it extremely bitter whereas some find it completely tasteless, being classified as a taster and a nontaster respectively. A majority of nontasters prefer foods with sweeter and stronger flavors, thus making them more susceptible to dental caries.
View Article and Find Full Text PDFDesign, Synthesis, Docking Studies, and Biological Evaluation of Novel 2-Hydroxyacetophenone Derivatives as Anti-HIV-1 Agents.
Curr HIV Res
January 2024
Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: The persistence of HIV mutations and the existence of multidrug resistance have produced an opportunity for an array of innovative anti-HIV medicines with a variety of structures that target HIV key enzymes.
Objective: The goal of this work was to find a new class of anti-HIV drugs founded on HIV integrase inhibitor pharmacophores.
Methods: A novel class of 2-hydroxy acetophenone analogs featuring substituted benzamide or N-phenylthiourea groups was designed and synthesized based on the general pharmacophore of HIV-1 integrase inhibitors (INs).
TAS2R38 bitter taste perception in the Koṅkaṇī Sārasvata Brahmin population.
Genes Genomics
November 2023
Department of Applied Zoology, Mangalore University, Mangalagangotri, Mangaluru, 574199, India.
Background: The TAS2R38 gene carries markers for phenylthiocarbamide (PTC) sensitivity. Various studies have investigated the genotype-phenotype association pattern for bitter tasting ability and other factors in different populations. However, a paucity of such information for endogamous Indian populations is the reason behind this study.
View Article and Find Full Text PDFSelf-assembled thiophanate-methyl/star polycation complex prevents plant cell-wall penetration and fungal carbon utilization during cotton infection by Verticillium dahliae.
Int J Biol Macromol
June 2023
Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Western Agricultural Research Center, Chinese Academy of Agricultural Sciences, Changji 831100, PR China. Electronic address:
Article Synopsis
- Researchers developed a novel nanodelivery system using a star polycation (SPc) to enhance the effectiveness of the fungicide thiophanate-methyl (TM) against Verticillium dahliae, which causes vascular wilt disease in plants.
- The SPc-coated TM significantly reduced the size of TM particles and improved its antifungal efficacy, achieving a substantial decrease in fungal colony size and spore count compared to TM alone.
- This new TM nanoagent not only halted key gene expressions in the pathogen but also showed minimal toxicity to cotton seeds, marking a significant advancement in managing Verticillium wilt effectively.
Gustatory dysfunction is related to Parkinson's disease: A systematic review and meta-analysis.
Int Forum Allergy Rhinol
October 2023
Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, South Korea.
Background: Olfactory dysfunction has been reported to be involved in Parkinson's disease (PD) pathogenesis. However, gustatory dysfunction in PD has not been evaluated as in-depth as olfactory dysfunction. We reviewed the previously published studies regarding gustatory function in PD patients and suggested the possibility that gustatory dysfunction may also be associated with PD.
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