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NUSAP1 Binds ILF2 to Modulate R-Loop Accumulation and DNA Damage in Prostate Cancer.
Int J Mol Sci
March 2023
Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Article Synopsis
- Increased expression of NUSAP1 serves as a strong prognostic biomarker in prostate cancer and promotes cancer invasion and metastasis regulated by E2F1.
- * Researchers identified 85 proteins that interact with NUSAP1, highlighting its role in maintaining R-loops and aiding in DNA damage response, particularly through interaction with ILF2.
- * Depleting ILF2 increases DNA damage, and NUSAP1's interaction with ILF2 is crucial in regulating R-loop formation, suggesting NUSAP1 as a potential target for cancer therapies.*
Visualization of Apoptosis in Three-Dimensional Cell Aggregates Based on Molecular Beacon Imaging.
Tissue Eng Part C Methods
April 2021
Laboratory of Biomaterials, Department of Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
The objective of this study is to visualize cell apoptosis in three-dimensional (3D) cell aggregates based on molecular beacons (MB). Two types of MB for messenger RNA were used: caspase-3 MB as a target for apoptosis and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) MB as a control of stable fluorescence in cells. To enhance the MB internalization into cells, caspase-3 and GAPDH MB were incorporated in cationized gelatin nanospheres (cGNS), respectively (cGNS and cGNS).
View Article and Find Full Text PDFNucleosome assembly protein 1-like 4, a new therapeutic target for proliferation and invasion of melanoma cells.
J Dermatol Sci
April 2021
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Background: Melanoma is one of the deadliest skin cancers. The treatment of advanced melanoma has been dramatically improved by immune checkpoint inhibitors and targeted therapies. However, many patients still do not respond to these therapies.
View Article and Find Full Text PDFFEN1 inhibitor synergizes with low-dose camptothecin to induce increased cell killing via the mitochondria mediated apoptotic pathway.
Gene Ther
August 2022
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, 1 WenYuan Road, 210023, Nanjing, China.
Camptothecin has been used in tumor therapy for a long time but its antitumor effect is rather limited due to the side effect and the drug resistance. FEN1, a major component of DNA repair systems, plays important roles in maintaining genomic stability via DNA replication and repair. Here we found that FEN1 inhibitor greatly sensitizes cancer cells to low-dose camptothecin.
View Article and Find Full Text PDFFun30 chromatin remodeler helps in dealing with torsional stress and camptothecin-induced DNA damage.
Yeast
February 2021
Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Fun30 is an ATP-dependent chromatin remodeler in budding yeast that is involved in cellular processes important for maintaining genomic stability such as gene silencing and DNA damage repair. Cells lacking Fun30 are moderately sensitive to the topoisomerase inhibitor camptothecin and exhibit a delay in cell cycle progression in the presence of camptothecin. Here, we show that Fun30 is required to cope with torsional stress in the absence of Top1.
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