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Cholinesterase Inhibitory and o Toxicity Assessment of Thirty-Four Isoquinoline Alkaloids - Berberine as the Lead Compound.
CNS Neurol Disord Drug Targets
June 2024
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara 06330, Türkiye.
Background: Cholinesterase (ChE) inhibitors used currently in clinics for the treatment of Alzheimer's disease (AD) are the most prescribed drug class with nitrogen-containing chemical formula. Galanthamine, the latest generation anti-ChE drug, contains an isoquinoline structure.
Objective: The aim of the current study was to investigate the inhibitory potential of thirty-four isoquinoline alkaloids, e.
In Silico Evaluation of Iranian Medicinal Plant Phytoconstituents as Inhibitors against Main Protease and the Receptor-Binding Domain of SARS-CoV-2.
Molecules
September 2021
Department of Agricultural Sciences, University of Naples Federico II, Portici, 80055 Naples, Italy.
The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially appeared in Wuhan, China, in December 2019. Elderly individuals and those with comorbid conditions may be more vulnerable to this disease. Consequently, several research laboratories continue to focus on developing drugs to treat this infection because this disease has developed into a global pandemic with an extremely limited number of specific treatments available.
View Article and Find Full Text PDF[Alkaloids from Macleaya cordata].
Zhongguo Zhong Yao Za Zhi
July 2009
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Objective: To study the alkaloids of Macleaya cordata.
Method: The alkaloids were isolated and purified by various column chromatography as well as recrystallization. Their structures were identified by physico-chemical properties and spectral analysis.
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