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Methods for pragmatic randomized clinical trials of pain therapies: IMMPACT statement.
Pain
October 2024
Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Pragmatic, randomized, controlled trials hold the potential to directly inform clinical decision making and health policy regarding the treatment of people experiencing pain. Pragmatic trials are designed to replicate or are embedded within routine clinical care and are increasingly valued to bridge the gap between trial research and clinical practice, especially in multidimensional conditions, such as pain and in nonpharmacological intervention research. To maximize the potential of pragmatic trials in pain research, the careful consideration of each methodological decision is required.
View Article and Find Full Text PDFLearning from five bad arguments against mandatory vaccination.
Vaccine
May 2023
Perelman School of Medicine and The Wharton School, University of Pennsylvania, 423, Guardian Drive, Blockley Hall, Philadelphia, PA 19104-4884, USA.
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement.
Pain
July 2023
Pain Research, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
Many questions regarding the clinical management of people experiencing pain and related health policy decision-making may best be answered by pragmatic controlled trials. To generate clinically relevant and widely applicable findings, such trials aim to reproduce elements of routine clinical care or are embedded within clinical workflows. In contrast with traditional efficacy trials, pragmatic trials are intended to address a broader set of external validity questions critical for stakeholders (clinicians, healthcare leaders, policymakers, insurers, and patients) in considering the adoption and use of evidence-based treatments in daily clinical care.
View Article and Find Full Text PDFThe potential of intravenous topiramate for the treatment of status epilepticus.
Epilepsy Behav
January 2023
Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria; Center for Cognitive Neuroscience, Salzburg, Austria.
There is considerable clinical evidence that topiramate (TPM) has a high potential in the treatment of refractory and super-refractory status epilepticus (RSE, SRSE). Because TPM is only approved for oral administration, it is applied as suspension via a nasogastric tube for SE treatment. However, this route of administration is impractical in an emergency setting and leads to variable absorption with unpredictable plasma levels and time to peak concentration.
View Article and Find Full Text PDFParatuberculosis control strategies in dairy cattle: A systematic review.
Open Vet J
September 2022
Centauro, Escuela de Medicina Veterinaria, Facultad de Ciencias Agrarias, Universidad de Antioquia UdeA, Medellín, Colombia.
Background: subsp. is the causative agent of paratuberculosis (PTB), incurable enterocolitis, affecting domestic and wild ruminants. Economic losses, impacts on animal health and welfare, and public health concerns justify its herd-level control.
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