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Pembrolizumab in gestational trophoblastic neoplasia: Systematic review and meta-analysis with sub-group analysis of potential prognostic factors.
Clinics (Sao Paulo)
March 2025
New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Objective: To assess the performance of pembrolizumab for the treatment of Gestational Trophoblastic Neoplasia (GTN).
Methods: The Medical Subject Headings related to immunotherapy/pembrolizumab and GTN were used alone or in combination to retrieve relevant articles. The authors searched in EMBASE, MEDLINE/PubMed, Elsevier's Scopus, and Web of Science until November/2024.
Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review.
Case Rep Womens Health
March 2025
Al Quds University Faculty of Medicine, Jerusalem, Palestine.
Choriocarcinoma is a rare, aggressive gestational trophoblastic disorder with metastatic potential, often presenting with abnormal bleeding and increasing levels of beta-human chorionic gonadotropin (b-hCG). Diagnosis is confirmed through histopathologic examination after curettage, and treatment typically involves stage-dependent chemotherapy. This case report concerns a 25-year-old woman with heavy postpartum bleeding, later diagnosed with choriocarcinoma.
View Article and Find Full Text PDFFactors influencing serum hCG negativization timing in gestational trophoblastic neoplasia.
Am J Cancer Res
January 2025
Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310003, Zhejiang, China.
Gestational trophoblastic neoplasia (GTN) refers to malignant diseases originating from placental trophoblast cells. Despite high complete remission rates with standard treatments, the adverse effects of chemotherapy, variation in treatment regimens, and the psychological impact on patients significantly influence the prognosis. This study aims to identify factors influencing the time to serum human chorionic gonadotropin (hCG) negativization, thereby contributing to the optimization of patient management strategies.
View Article and Find Full Text PDFThe clinical characteristics and prognostic analysis of 35 postterm choriocarcinomas.
BMC Cancer
February 2025
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20 The third section of South Renmin Road, Chengdu, 610041, Sichuan, China.
Objective: Postterm choriocarcinoma is rare and seldom reported. Patients with postterm choriocarcinoma have unfavorable outcomes. Thus, we conducted a retrospective study to better understand this disease.
View Article and Find Full Text PDFCombination chemotherapy with sintilimab for treatment of a male patient with primary pulmonary choriocarcinoma: a case report and literature review.
Front Immunol
February 2025
Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
Primary pulmonary choriocarcinoma (PPC) is an extremely rare malignant cancer in men with no clinical guidelines for the treatment. Cytotoxic chemotherapy has a limited effect on the prognosis of PPC. Recently, immune checkpoint inhibitors (ICIs) have shown promising treatment effectiveness.
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