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Oral microbiota as a biomarker for predicting the risk of malignancy in indeterminate pulmonary nodules: a prospective multicenter study.
Int J Surg
December 2024
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China.
Background: Determining the benign or malignant status of indeterminate pulmonary nodules (IPN) with intermediate malignancy risk is a significant clinical challenge. Oral microbiota-lung cancer interactions have qualified oral microbiota as a promising non-invasive predictive biomarker in IPN.
Materials And Methods: Prospectively collected saliva, throat swabs, and tongue coating samples from 1040 IPN patients and 70 healthy controls across three hospitals.
Gut Microbiota as Mediator and Moderator Between Hepatitis B Virus and Hepatocellular Carcinoma: A Prospective Study.
Cancer Med
December 2024
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Background: The impact of gut microbiome on hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is unclear. We aimed to evaluate the potential correlation between gut microbiome and HBV-related HCC and introduced novel machine learning (ML) signatures based on gut microbe to predict the risk of HCC.
Materials And Methods: A total of 640 patients with chronic liver diseases or HCC were prospectively recruited between 2019 and 2022.
The mouth of America: the oral microbiome profile of the US population.
medRxiv
December 2024
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD., USA.
Importance: The oral microbiome is increasingly recognized to play key roles in human health and disease; yet, population-representative characterizations are lacking.
Objective: Characterize the composition, diversity, and correlates of the oral microbiome among US adults.
Design: Cross-sectional population-representative survey.
Alterations of oral microbiota in young children with autism: Unraveling potential biomarkers for early detection.
J Dent
January 2025
Department of Psychology, The University of Hong Kong, Hong Kong SAR, PR China. Electronic address:
Article Synopsis
- The study examined the oral microbiota of young children with autism spectrum disorder (ASD), finding notable differences in microbial composition compared to typically developing (TD) children.
- Analysis of dental plaque samples from 25 ASD children and 30 TD children revealed lower bacterial diversity in the ASD group and identified six specific species present in ASD children that were not found in TD children, indicating potential biomarkers for ASD.
- The research suggests that differences in oral microbiota may play a role in understanding ASD and points to the need for further validation of these findings for early detection and management of the disorder.
Findings and methodologies in oral phageome research: a systematic review.
J Oral Microbiol
October 2024
Shenzhen Clinical College of Stomatology, School of Stomatology, Southern Medical University, Shenzhen, Guangdong, China.
Background: The oral microbiome serves as both an indicator and a mediator of oral health. Evidence indicates that bacteriophages (phages) are widely present in the oral microbiome and exhibit diverse classifications and interactions with human cells and other microbes. These phages constitute the oral phageome, which potentially exerts significant yet unexplored effects on the interplay between oral and general health.
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