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Amino acid modified copper-based metal organic polyhedral with higher peroxidase activity for potassium guaiacol sulfonate detection.
Sci Rep
January 2025
School of Chemical Science and Technology, Key Laboratory of Medicinal Chemistry for Natural Resource, Yunnan University, No. 2 North Cuihu Road, Kunming, China.
It has been reported some nanozymes could be used as a substitute for natural enzyme to detect HO to some extent. However, the low catalytic effect of these materials limited their further application fields. Hence, to increase the catalytic activity of nanozymes was a hot research topic and many methods have been reported.
View Article and Find Full Text PDFA New Type of Bioprosthetic Heart Valve: Synergistic Modification with Anticoagulant Polysaccharides and Anti-inflammatory Drugs.
ACS Biomater Sci Eng
January 2025
College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, P.R. China.
Valvular heart disease (VHD) poses a significant threat to human health, and the transcatheter heart valve replacement (THVR) is the best treatment for severe VHD. Currently, the glutaraldehyde cross-linked commercial bioprosthetic heart valves (BHVs) remain the first choice for THVR. However, the cross-linking by glutaraldehyde exhibits several drawbacks, including calcification, inflammatory reactions, and difficult endothelialization, which limits the longevity and applicability of BHVs.
View Article and Find Full Text PDFCarbon-based light addressable potential aptasensor based on the synergy of C-MXene@rGO and OPD@NGQDs for low-density lipoprotein detection.
Mikrochim Acta
December 2024
School of Life and Environmental Sciences, School of Intellectual Property, Guilin University of Electronic Technology, Guilin, Guangxi, 541004, People's Republic of China.
A novel carbon-based light-addressable potentiometric aptasensor (C-LAPS) was constructed for detection low-density lipoprotein (LDL) in serum. Carboxylated TiC MXene @reduced graphene oxide (C-MXene@rGO) was used as interface and o-phenylenediamine functionalized nitrogen-doped graphene quantum dots (OPD@NGQDs) as the photoelectric conversion element. The photosensitive layers composed of OPD@NGQDs/C-MXene@rGO exhibit superior photoelectric conversion efficiency and excellent biocompatibility, which contribute to an improved response signal.
View Article and Find Full Text PDFCharacterization of acidic lysine acylations in mycobacteria.
Front Microbiol
December 2024
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Article Synopsis
- Protein acetylation is a widely studied post-translational modification, and recent research has identified three new forms: lysine malonylation, succinylation, and glutarylation, which mainly affect energy metabolism in diseases caused by Mycobacterium pathogens.
- Methods involved using high-affinity antibody enrichment and LC-MS/MS analysis to characterize these new lysine modifications and assess their functional impacts in certain proteins.
- Results showed significant global substrate characterization for these acylations, revealing connections to ribosomal function and various metabolic pathways, highlighting their importance in cellular processes.
A click chemistry-based biorthogonal approach for the detection and identification of protein lysine malonylation for osteoarthritis research.
bioRxiv
December 2024
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine (HCOM), Ohio University, Athens, OH, 45701, USA.
Lysine malonylation is a post-translational modification where a malonyl group, characterized by a negatively charged carboxylate, is covalently attached to the Ɛ-amino side chain of lysine, influencing protein structure and function. Our laboratory identified Mak upregulation in cartilage under aging and obesity, contributing to osteoarthritis (OA). Current antibody-based detection methods face limitations in identifying Mak targets.
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