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Impact of Hypothyroidism in Pregnancy on Feto-Maternal Outcomes: A Prospective Observational Study.
Cureus
November 2024
Department of Pathology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed To Be University), Karad, IND.
Introduction Hypothyroidism represents an endocrine disorder marked by the insufficient production of hormones by the thyroid gland, with significant effects on bodily functions. Its occurrence during pregnancy is of particular concern due to its profound effects on both maternal and fetal health outcomes. Aim To study the impact of hypothyroidism in pregnancy and its correlation with feto-maternal outcomes.
View Article and Find Full Text PDFOff to a good start: The importance of the placental exchange surface - Lessons from the mouse.
Dev Biol
January 2025
Dept. of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada; Alberta Children's Hospital Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada. Electronic address:
The role of the chorio-allantoic placenta as the critical nutrient- and oxygen-supplying organ to nourish the demands of the fetus has been well recognized. This function relies on the successful establishment of the placental feto-maternal exchange unit, or interhaemal barrier, across which all nutrients as well as waste products must pass to cross from the maternal to the fetal blood circulation, or vice versa, respectively. As a consequence, defects in the establishment of this elaborate interface lead to fetal growth retardation or even embryonic lethality, depending on the severity of the defect.
View Article and Find Full Text PDFThe utilization of artificial intelligence in enhancing 3D/4D ultrasound analysis of fetal facial profiles.
J Perinat Med
November 2024
Department of Obstetrics and Gynecology, Medical School University of Zagreb, Zagreb, Croatia.
Artificial intelligence (AI) has emerged as a transformative technology in the field of healthcare, offering significant advancements in various medical disciplines, including obstetrics. The integration of artificial intelligence into 3D/4D ultrasound analysis of fetal facial profiles presents numerous benefits. By leveraging machine learning and deep learning algorithms, AI can assist in the accurate and efficient interpretation of complex 3D/4D ultrasound data, enabling healthcare providers to make more informed decisions and deliver better prenatal care.
View Article and Find Full Text PDFSpatiotemporally distinct roles of cyclooxygenase-1 and cyclooxygenase-2 at fetomaternal interface in mice.
JCI Insight
August 2024
Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Article Synopsis
- Embryo implantation is essential for a healthy pregnancy and is influenced by changes in gene expression and metabolism in the uterus, which respond to hormones and embryo signals.
- Researchers used spatial transcriptomic analysis to identify that lipid metabolism, particularly pathways related to arachidonic acid, is important in the uterus during implantation.
- The study found that the COX2 enzyme plays a crucial role in successful implantation, while the absence of COX1 or COX2 leads to impaired pregnancy or infertility, highlighting the distinct functions of each enzyme in this process.*
A Comparative Study of Coagulation Profiles in Preeclamptic and Normotensive Patients in Relation to Maternal and Fetal Outcomes.
Cureus
August 2024
Obstetrics and Gynecology, Dr. D Y Patil Medical College, Hospital and Research Centre, Dr. D Y Patil Vidyapeeth (Deemed to be University) Pimpri, Pune, IND.
Article Synopsis
- Hypertensive complications, particularly preeclampsia, are crucial factors contributing to higher maternal and neonatal health risks in pregnancy globally, marked by high blood pressure and proteinuria, along with serious blood-related issues.
- A study was conducted comparing coagulation profiles and pregnancy outcomes between 37 women diagnosed with preeclampsia and 37 with normal blood pressure, analyzing various coagulation parameters and maternal/neonatal health outcomes from September 2022 to May 2024.
- Findings revealed significantly lower platelet counts in preeclamptic women, along with other complications such as increased risks for serious maternal health issues and varied neonatal outcomes, indicating the severe impact of preeclampsia on both mothers and their infants.
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