Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3181/00379727-140-36690 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Berberine regulates glucose and lipid metabolism via clock-controlled genes to ameliorate insulin resistance of hepatocytes].
Zhongguo Zhong Yao Za Zhi
December 2024
Jiangxi Province Key Laboratory of Traditional Chinese Medicine Etiopathogenisis & Research Center for Differentiation and Development of Traditional Chinese Medicine Basic Theory, Jiangxi University of Chinese Medicine Nanchang 330004,China.
This study aims to investigate the mechanism of berberine in regulating the metabolism network via clock-controlled genes represented by brain and muscle arnt-like 1(BMAL1) to ameliorate insulin resistance(IR) of hepatocytes in vitro. The HepG2 cell model of dexamethasone-induced IR(IR-HepG2) was established and treated with 5, 10, and 20 μmol·L~(-1) berberine, respectively, for 24 h. The glucose oxidase method and cell counting kit-8(CCK-8) assay were employed to measure extracellular glucose concentration and cell viability, respectively.
View Article and Find Full Text PDFHigh Glucose Inhibits O-GlcNAc Transferase Translocation in Early Osteoblast Differentiation by Altering Protein Phosphatase 2A Activity.
J Cell Physiol
January 2025
Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Our previous study revealed a link between O-GlcNAc transferase (OGT) localization and protein phosphatase 2A (PP2A) activity in osteoblast. Given the association of PP2A downregulation with osteoblast differentiation, we hypothesized that OGT localization changes during this process. We examined OGT localization in MC3T3-E1 cells undergoing differentiation under normal and high glucose conditions.
View Article and Find Full Text PDFEvaluation of growth, nutrient utilization, and metabolic function in rohu, Labeo rohita (Hamilton), fed diets incorporated with fermented Saraca asoca leaf meal.
Fish Physiol Biochem
January 2025
Aquaculture Laboratory, Department of Zoology, The University of Burdwan, Golapbag, Burdwan, 713104, West Bengal, India.
The present study evaluated the potential of Ashoka, Saraca asoca leaf meal (SLM), in carp diets following fermentative processing with a tannase-producing fish gut bacterium, Bacillus subtilis (KP765736). The processing of SLM led to a significant (P < 0.05) reduction in major anti-nutrients (tannin, trypsin inhibitor, and crude fiber), while crude protein content increased.
View Article and Find Full Text PDFNek6 regulates autophagy through the mTOR signaling pathway to alleviate cerebral ischemia-reperfusion injury.
Mol Brain
December 2024
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No. 1 Eastern Jian-She Road, Zhengzhou, 450052, Henan, China.
Objective: Cerebral ischemia-reperfusion injury (CIRI) is a major obstacle to neurological recovery after clinical treatment of ischemic stroke. The aim of this study was to investigate the molecular mechanism of Nek6 alleviating CIRI through autophagy after cerebral ischemia.
Materials And Methods: A mouse model of CIRI was constructed by middle cerebral artery occlusion (MCAO).
[Salidroside alleviates high glucose and ethanol-induced pyroptosis in insulinoma cells].
Zhongguo Zhong Yao Za Zhi
November 2024
School of Pharmaceutical Sciences, Hubei University of Medicine Shiyan 442000, China Institute of Wudang Traditional Chinese Medicine, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China Department of Pharmacy, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
This study established a pyroptosis injury model by stimulating insulinoma cells(INS-1) of rats with high glucose(HG) and observed the impact of additional ethanol(ET) exposure on cell pyroptosis, as well as the intervention effect of salidroside(SAL). INS-1 cells were cultured and divided into a normal control group(NG), an HG group, an HG + ET(100 mmol·L~(-1)) group, and an HG + ET + SAL(1-100 μmol·L~(-1)) group. After 72 hours of treatment, cell viability was assessed using the cell counting kit-8(CCK-8) assay.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!