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Use of Crithidia fasciculata extract for the facile enzymatic synthesis of GDP-L-[3H]Fucose.
Glycobiology
January 2025
Wellcome Centre for Anti-Infectives Research, Biological Chemistry and Drug Discovery, School of Life Sciences, Dow Street, University of Dundee, Dundee DD1 5HN, United Kingdom.
For studies involving glycosyltransferases and nucleotide sugar transporters, radioactive nucleotide sugars are critical reagents. Of these, GDP-L-[3H]Fucose is currently commercially unavailable. Here, we present a facile approach for the preparation of GDP-[3H]-L-Fucose, using the enzymatic machinery present in the cytosol of the non-infectious and easily cultivated protozoan, Crithidia fasciculata, and its purification by solid phase extraction ion exchange chromatography.
View Article and Find Full Text PDFAdhesion of promotes a rapid change in developmental fate driven by cAMP signaling.
mSphere
October 2024
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Trypanosomatids are single-celled parasites responsible for human and animal disease. Typically, colonization of an insect host is required for transmission. Stable attachment of parasites to insect tissues their single flagellum coincides with differentiation and morphological changes.
View Article and Find Full Text PDFA proposed pathway from D-glucose to D-arabinose in eukaryotes.
J Biol Chem
August 2024
Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland, UK. Electronic address:
Article Synopsis
- * This study investigates the conversion of D-Glc to D-Ara in the trypanosomatid Crithidia fasciculata, finding that both arms of the pentose phosphate pathway are involved, along with the function of a specific enzyme (GFAT).
- * The research suggests a general pathway for producing D-Ara from D-Glc in eukaryotes, highlighting its roles in synthesizing important compounds, including
Genetic modification of the bee parasite Crithidia bombi for improved visualization and protein localization.
Exp Parasitol
July 2024
Department of Biology, Villanova University, Villanova, PA, 19085, USA. Electronic address:
Crithidia bombi is a trypanosomatid parasite that infects several species of bumble bees (Bombus spp.), by adhering to their intestinal tract. Crithidia bombi infection impairs learning and reduces survival of workers and the fitness of overwintering queens.
View Article and Find Full Text PDFA conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense.
PLoS Pathog
February 2024
Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth laboratories, Charlotte Auerbach Road, Edinburgh, United Kingdom.
Trypanosomatid parasites undergo developmental regulation to adapt to the different environments encountered during their life cycle. In Trypanosoma brucei, a genome wide selectional screen previously identified a regulator of the protein family ESAG9, which is highly expressed in stumpy forms, a morphologically distinct bloodstream stage adapted for tsetse transmission. This regulator, TbREG9.
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