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Duplication of the Plantaris Tendon and Its Clinical Significance: A Case Report.

Cureus

December 2024

Orthopedics and Traumatology, Unidade Local de Saúde do Nordeste, Macedo de Cavaleiros, PRT.

The plantaris tendon may be absent in some individuals, indicating its unclear function. Anatomically, the plantaris tendon originates from the lateral femoral condyle and has a variable course and insertion point at the calcaneal tuberosity. The plantaris tendon may influence conditions such as Achilles tendinopathy, particularly in its midportion, whether by its close relation to the calcaneal tendon or adhesions between both tendons.

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Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors that arise from interstitial cells of Cajal. Due to vague presentation, location and confusing imaging studies, they tend to mimic gynaecological tumors. They usually diagnosed intra-operative and histopathology followed by tumor specific receptors such as KIT, CD34, CD 117 and DOG 1 are mainstay of diagnosis of GIST.

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[Empowering patients through app-based cochlear implant self-adjustment].

HNO

January 2025

Deutsches Hörzentrum der Medizinischen Hochschule Hannover, Karl-Wiechert-Allee 3, 30625, Hannover, Deutschland.

Treatment of patients with severe hearing loss or deafness using cochlear implants (CI) is nowadays clinical routine. In the Hannover Medical School alone, more than 500 patients are treated with CI annually, meaning that the pool of patients with CI increases significantly each year. Worldwide, there are over 1 million patients with a CI system; in Germany the figure is estimated at over 60,000.

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This is a retrospective cross-sectional diagnostic test accuracy study of direct immunofluorescence (DIF) performed on a group of potential lupus erythematosus (LE)/dermatomyositis (DM) skin biopsies from 2015 to 2020 at a large, academic medical center. For purposes of this study, which was focused primarily on detection of LE/DM-related interface dermatitis, DIF was considered positive for a LE/DM pattern if it showed granular deposition of immunoglobulin G, with or without C3, at the basement membrane zone on the final pathology report. Blinded clinicopathologic correlation was the reference standard.

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Refining fine-mapping: Effect sizes and regional heritability.

PLoS Genet

January 2025

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

Recent statistical approaches have shown that the set of all available genetic variants explains considerably more phenotypic variance of complex traits and diseases than the individual variants that are robustly associated with these phenotypes. However, rapidly increasing sample sizes constantly improve detection and prioritization of individual variants driving the associations between genomic regions and phenotypes. Therefore, it is useful to routinely estimate how much phenotypic variance the detected variants explain for each region by taking into account the correlation structure of variants and the uncertainty in their causal status.

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