Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Craniosynostosis-4 with Heterozygous Mutation in the Gene: A Case Report.
Int J Clin Pediatr Dent
October 2024
Department of Pedodontics and Preventive Dentistry, Govt. Dental College & Hospital, Puducherry, India.
Article Synopsis
- Craniosynostosis (CS) is a condition where cranial sutures fuse prematurely, affecting 1 in 2,000-2,500 children, and can be categorized as syndromic or nonsyndromic based on the affected sutures.
- An 8-year-old girl displayed signs of CS, and genetic testing identified a mutation linked to craniosynostosis-4, while her dental evaluation revealed unerupted teeth and cavities.
- Treatment involved addressing dental issues, and the significance of CS includes its genetic basis, often involving new mutations, with associated complications like facial changes and developmental delays.
Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy.
Biochem Pharmacol
January 2025
UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, D04 V1W8, Ireland. Electronic address:
As a multifactorial and heterogeneous disease, cancer has a high mortality rate, and the search for more effective treatments is an enormous challenge. Metal coordination compounds open a range of possibilities that conventional organic and biological molecules can no longer fulfil due to increasing drug resistance. Metallodrugs still have tremendous potential to help overcome drug resistance and find new cures in medicine, considering that at least 25 metallic elements participate in healthy functioning of the human body.
View Article and Find Full Text PDFPrecision Population Cancer Medicine in Brain Tumors: A Potential Roadmap to Improve Outcomes and Strategize the Steps to Bring Interdisciplinary Interventions.
Cureus
October 2024
Department of Radiotherapy and Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, IND.
Brain tumors, a significant health burden, rank as the second leading cause of cancer among adolescents and young adults and the eighth most common cancer in older adults. Despite treatment advances, outcomes for many brain tumor types, especially glioblastoma multiforme (GBM), remain poor. Precision population cancer medicine (PPCM) offers promising avenues for improving outcomes in brain tumor management.
View Article and Find Full Text PDFTranslation of Deoxyribonucleic Acid into Synthetic Alpha Helical Peptides for Darwinian Evolution.
JACS Au
October 2024
Department of Organic Chemistry, Faculty of Sciences, University of Geneva, Geneva 1211, Switzerland.
DNA-encoded libraries connect the phenotypes of synthetic molecules to a DNA barcode; however, most libraries do not tap into the potential of Darwinian evolution. Herein, we report a DNA-templated synthesis (DTS) architecture to make peptides that are stabilized into α-helical conformations via head-to-tail supramolecular cyclization. Using a pilot library targeting MDM2, we show that repeated screening can amplify a binder from the lowest abundance in the library to a ranking that correlates to binding affinity.
View Article and Find Full Text PDFMendelian study on air pollution and membranous nephropathy outcomes associations.
Medicine (Baltimore)
September 2024
Department of Breast and Thyroid Surgery, First People's Hospital of Kunming City & Calmette Affiliated Hospital of Kunming Medical University, Kunming, China.
Membranous nephropathy (MN) is an autoimmune disease of the kidney glomerulus, which mainly leads to nephrotic syndrome. This study investigates the associations between air pollution and MN risk and from an epigenomic perspective. In this study, we examine the associations between genetically predicted deoxyribonucleic acid methylation related to air pollution and MN risk.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!