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Single-cell and spatial transcriptomic profiling revealed niche interactions sustaining growth of endometriotic lesions.
Cell Genom
January 2025
National Clinical Research Center for Obstetric & Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. Electronic address:
Endometriosis is a chronic condition with limited therapeutic options. The molecular aberrations promoting ectopic attachment and interactions with the local microenvironment sustaining lesion growth have been unclear, prohibiting development of targeted therapies. Here, we performed single-cell and spatial transcriptomic profiling of ectopic lesions and eutopic endometrium in endometriosis.
View Article and Find Full Text PDFWhere is menstruation in global health policy? The need for a collective understanding.
Glob Public Health
December 2025
Department of Social and Policy Science, University of Bath, Bath, UK.
From both an academic and a policy angle, menstruation is receiving an unprecedented level of attention. Within the academic literature, there are many different normative arguments being furthered for how menstruation be understood and framed - variously, that it should be understood as an issue of rights, justice, health or hygiene management. Yet less attention has been paid to the step preceding these normative arguments - how menstruation actually understood at present within global health policy.
View Article and Find Full Text PDFUsing natural spline models to explore the trajectories of empirically derived domains of premenstrual symptoms.
Psychol Assess
January 2025
University of Miami, Department of Psychology.
Premenstrual symptoms are distressing and impairing for individuals and costly to society. These symptoms are heterogeneous within and across people, dimensional, and dynamic. While some efforts have been made to understand the trajectories of premenstrual symptoms, two major gaps in the literature remain.
View Article and Find Full Text PDFThe effects of melatonin on follicular oxidative stress and art outcomes in women with diminished ovarian reserve: a randomized controlled trial.
J Ovarian Res
January 2025
Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Background: To investigate the impact of Melatonin on follicular oxidative stress and assisted reproductive technology (ART) outcomes in women with diminished ovarian reserve (DOR).
Method: We put 68 women with DOR who were going through ART into a randomized controlled trial. Starting on the fifth day of their menstrual cycle, we gave them either 3 mg of Melatonin or a placebo every day before stimulating their ovaries.
Multiple physiological changes occur during the menstrual cycle; many are attributed to fluctuations in estrogen, luteinizing hormone, follicle-stimulating hormone, and progesterone. These hormones differentially affect the menstrual cycle's follicular, ovulation, and luteal phases. Skin is one of the organs affected by changes in a woman's menstrual cycle.
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