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In Brief: Transgender, non-binary and gender-diverse patients utilizing feminizing gender-affirming hormone therapy (GAHT) may experience reduced fertility, which is currently addressed through fertility preservation and treatment cessation. Experimental research with animal models may identify mechanisms involved in testicular function impairment, their severity and duration, and may help to inform patients about reproductive health decisions.
Abstract: Feminizing GAHT may include combined estrogen, progesterone and/or antiandrogens (collectively referred to as E-GAHT) aiming to achieve individualized embodiment goals.
Soma-germline communication drives sex maintenance in the testis.
Natl Sci Rev
August 2024
Shenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
In adult gonads, disruption of somatic sexual identity leads to defective gametogenesis and infertility. However, the underlying mechanisms by which somatic signals regulate germline cells to achieve proper gametogenesis remain unclear. In our previous study, we introduced the ( ) mutant testis phenotype as a valuable model for investigating the mechanisms underlying sex maintenance.
View Article and Find Full Text PDF[Estrogen receptor Esr1 induces early ovarian differentiation in ].
Sheng Wu Gong Cheng Xue Bao
July 2024
Institute of Animal Sex and Development, Zhejiang Wanli University, Ningbo 315100, Zhejiang, China.
This study aims to explore the roles of three estrogen receptors (Esr1, Esr2, and Gper1) in early differentiation of embryonic gonads of . The expression characteristics of the receptor genes were studied first. The Esr1, Esr2, and Gper1 agonists PPT, WAY 200070, and G-1 were respectively injected into the embryos at the male-producing temperature (MPT) before initiation of gonadal differentiation.
View Article and Find Full Text PDFHybridization between Aedes aegypti and Aedes mascarensis mosquitoes leads to disruption of male sex determination.
Commun Biol
July 2024
Department of Entomology, Virginia Polytechnic and State University, Blacksburg, VA, USA.
Understanding the sex determination pathway and its disruptions in mosquitoes is critical for the effective control of disease vectors through genetic manipulations based on sex separation. When male hybrids of Aedes aegypti females and Ae. mascarensis males are backcrossed to Ae.
View Article and Find Full Text PDFGsdf is not indispensable for male differentiation in the medaka species Oryzias hubbsi.
Biochem Biophys Res Commun
September 2024
Laboratory of Molecular Reproductive Biology, Institute for Environmental Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan; Department of Environmental Life Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan.
Article Synopsis
- - The study explores the function of the Gonadal soma-derived growth factor (Gsdf) gene in sex determination within the medaka fish species, Oryzias hubbsi, which has a ZW sex-determination system.
- - While Gsdf shows male-dominant expression, knockout experiments indicate there’s no sex reversal and that genetic sex determination pathways remain normal without Gsdf, suggesting a different mechanism for sex differentiation in this species.
- - The loss of Gsdf results in germ cell overproliferation and quicker entry into meiosis in testes but lacks the feminizing effects seen in related species, underscoring the complexity and variability of sex determination across different fish species.
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