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One-step colorimetric immunosensing of foodborne bacteria using static magnet driven magnetophoretic separation and dual noble metal decorated magnetic nanobeads.
Anal Chim Acta
May 2025
Key Laboratory of Smart Agriculture System Integration, Ministry of Education, China Agricultural University, Beijing, 100083, China. Electronic address:
Background: Immunomagnetic separation is essential for screening pathogenic bacteria to prevent food poisoning. However, free immunomagnetic nanobeads (IMNBs) coexist with IMNB-bacteria conjugates (IBCs) after traditional immunomagnetic separation resulting in the infeasibility for IMNBs on IBCs to further act as signal label in bacterial detection. Although we have demonstrated that magnetophoretic separation at a high flowrate could separate IBCs from IMNBs, partial IMNBs were still found with IBCs due to chaotic flows and resulted in inevitable interferences.
View Article and Find Full Text PDFNeglected Microbes in Floral Nectar: Influence of Filamentous Fungi on Nectar Scent and Parasitoid Olfactory Responses.
J Chem Ecol
March 2025
Department of Agricultural, Food and Forest Sciences, University of Palermo, Palermo, 90128, Italy.
Floral nectar is a sugar-rich resource which is ubiquitously inhabited by a wide array of microorganisms. Fermentation by nectar-inhabiting microbes can alter several nectar traits, including nectar scent, via changes in the blend of volatile organic compounds (VOCs). Although there is growing evidence on how yeasts and bacteria influence the foraging behavior of flower-visiting insects, the potential role of other microbial taxa that can colonize nectar has been largely neglected.
View Article and Find Full Text PDFMicrobiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver.
Gut Microbes
December 2025
Division of Digestive & Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Despite extensive investigations into the microbiome and metabolome changes associated with colon polyps and colorectal cancer (CRC), the microbiome and metabolome profiles of individuals with colonic polyposis, including those with (Gene-pos) and without (Gene-neg) a known genetic driver, remain comparatively unexplored. Using colon biopsies, polyps, and stool from patients with Gene-pos adenomatous polyposis ( = 9), Gene-neg adenomatous polyposis ( = 18), and serrated polyposis syndrome (SPS, = 11), we demonstrated through 16S rRNA sequencing that the mucosa-associated microbiota in individuals with colonic polyposis is representative of the microbiota associated with small polyps, and that both Gene-pos and SPS cohorts exhibit differential microbiota populations relative to Gene-neg polyposis cohorts. Furthermore, we used these differential microbiota taxa to perform linear discriminant analysis to differentiate Gene-neg subjects from Gene-pos and from SPS subjects with an accuracy of 89% and 93% respectively.
View Article and Find Full Text PDFTBC1D30 regulates proinsulin and insulin secretion and is the target of a genomic association signal for proinsulin.
Diabetologia
March 2025
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Aims/hypothesis: Components of the insulin processing and secretion pathways remain incompletely understood. Here, we examined a genome-wide association study (GWAS) signal for plasma proinsulin levels. Lead GWAS variant rs150781447-T encodes an Arg279Cys substitution in TBC1 domain family member 30 (TBC1D30), but no role for this protein in insulin processing or secretion has been established previously.
View Article and Find Full Text PDFH-NMR-Based Biochemometric Strategy to Identify Transient Receptor Potential Vanilloid 1-Stimulating Compounds from Alpinia officinarum Rhizome.
Chem Pharm Bull (Tokyo)
March 2025
School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
This study established a H-NMR-based biochemometric approach for the isolation of biologically active compounds from complex extracts. In both pharmacognosy and natural product chemistry, reliably isolating bioactive compounds typically necessitates repeating time-consuming and laborious isolation and purification steps, presenting a bottleneck in many studies. We applied biochemometric methods to accurately estimate active compounds, thus minimizing the number of assays and isolation steps.
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