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The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate.
Trials
January 2025
Université Côte d'Azur, CNRS, LP2M, Nice, France.
Background: /aims. Pseudoxanthoma Elasticum (PXE, OMIM 264800) is an autosomal, recessive, metabolic disorder characterized by progressive ectopic calcification in the skin, the vasculature and Bruch's membrane. Variants in the ABCC6 gene are associated with low plasma pyrophosphate (PPi) concentration.
View Article and Find Full Text PDFAtmospheric cold plasma alters plant traits and negatively affects the growth and development of fall armyworm in rice.
Sci Rep
January 2025
Department of Entomology and Plant Pathology, University of Arkansas, Fayetteville, AR, 72701, USA.
Plasma is considered as the fourth state of matter, and atmospheric cold plasma (cold plasma) is a type of plasma consisting of ionized gases containing excited species of atoms, molecules, ions, and free radicals at near room temperature. Cold plasma is generated by applying high voltage to gases, causing it to ionize thus forming plasma. Although cold plasma has been found to break seed dormancy and improve germination rate, only a few studies have explored the potential of cold plasma against insect herbivory.
View Article and Find Full Text PDFConfinement-induced Ni-based MOF formed on TiCT MXene support for enhanced capacitive deionization of chromium(VI).
Sci Rep
January 2025
School of Environmental Science and Engineering, Yancheng Institute of Technology, Yancheng, 224051, People's Republic of China.
MXenes, as a novel two-dimensional lamellar material, has attracted much attention. However, MXenes lamellar are prone to collapse and stacking under hydrogen bonding and interlayer van der Waals forces, which affects their electrochemical and capacitive deionization performance. A three-dimensional Ni-1,3,5-benzenetricarboxylate/TiCT (Ni-BTC/TiCT) composite electrode material was developed to enhance the electrochemical and capacitive deionization performance.
View Article and Find Full Text PDFIon beam induced secondary electron tomography of acrylonitrile-styrene-acrylate/polycarbonate polymer blends for fused filament fabrication and injection moulding.
Sci Rep
January 2025
Departamento de Ciencia de los Materiales e Ingeniería Metalúrgica y Química Orgánica, IMEYMAT, Universidad de Cádiz, Campus Río San Pedro, 11510, Puerto Real, Cádiz, Spain.
Polymer blending is an interesting strategy to broaden the combination of properties available for a variety of applications. To understand the behaviour of the new materials obtained as well as the influence of the fabrication parameters used, methods to analyse the distribution of polymers in the blend with resolution below the micrometer are required. In this work, we demonstrate the capability of focused ion beam (FIB) tomography to provide 3D information of the polymer distribution in objects obtained by blending acrylonitrile-styrene-acrylate (ASA) with polycarbonate (PC) (50 wt%), fabricated by Fused Filament Fabrication (FFF) and by Injection Moulding (IM).
View Article and Find Full Text PDFCobalt polygalacturonates and the pharmacological composition based on them: Preparation, properties and cytotoxicity.
Int J Biol Macromol
January 2025
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, Kazan, Russia.
The aim of the present study was to obtain new metal complexes of citrus pectin with cobalt ions based on potassium polygalacturonate and to prepare a new pharmacological composition (PC) PGKCo: PGNaCo (1:1) with antitumor activity based on potassium cobalt polygalacturonate (PGKCo) and sodium cobalt polygalacturonate (PGNaCo). The study of the effect of PGKCo, PGNaCo and PC on the cell viability of tumor cell lines of different genesis in vitro showed that the obtained compounds are soluble in water and exhibit selective cytotoxic activity against the tumor cell lines of human lung carcinoma A549, breast adenocarcinoma MCF-7 and cervical carcinoma M-HeLa, with no significant toxic effect on normal human cells. The possible mechanism of action of the investigated PC on M-HeLa cancer cells was investigated.
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