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Arctiin suppress Th17 cells response and ameliorates experimental autoimmune uveitis through JAK/STAT signaling.
Cell Immunol
January 2025
Department of Rheumatology, Jincheng People 's Hospital, Shanxi Province, China.
Conventional treatments for autoimmune uveitis, such as corticosteroids and systemic immunosuppressants, often result in adverse side effects, prompting the need for therapies targeting specific molecular pathways. This study investigates the effects of Arctiin, known for its diverse biological properties, on experimental autoimmune uveitis (EAU) through its action on Th17 cells and the JAK/STAT signaling pathway. Our findings reveal that Arctiin significantly alleviates EAU by reducing clinical scores, inflammatory cell infiltration, and levels of inflammatory cytokines like IL-17 and TNF-α in the eye.
View Article and Find Full Text PDFNew therapies in celiac disease.
Curr Opin Gastroenterol
January 2025
Gastrointestinal Unit, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.
Purpose Of Review: Celiac disease (CeD) is a chronic autoimmune disorder of the small intestine triggered by gluten ingestion in genetically predisposed individuals. The cornerstone of CeD management remains a strict adherence to a lifelong gluten-free diet (GFD), although such a dietary restriction can lead to an altered quality of life and may not be easy to follow for many patients. These challenges highlighted the need for alternative therapies.
View Article and Find Full Text PDFA literature review of recent advances in gastric cancer treatment: exploring the cross-talk between targeted therapies.
Cancer Cell Int
January 2025
Cancer Immunology and Immunotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Background: Gastric cancer (GC) ranks fourth in global mortality rates and fifth in prevalence, making it one of the most common cancers worldwide. Recent clinical studies have highlighted the potential of immunotherapies as a promising approach to treating GC. This study aims to shed light on the most impactful therapeutic strategies in the context of GC immunotherapy, highlighting both established and emerging approaches.
View Article and Find Full Text PDFUnveiling the broad spectrum efficacy of volatile terpenes to fight against SARS-COV-2-associated mucormycosis.
Chem Biodivers
January 2025
Deraya University, Pharmacognosy, New Minia, New Minia, EGYPT.
Mucormycosis, a life-threatening fungal infection caused by Mucorales, affects immunocompromised patients, especially SARS-CoV-2 ones. Existing antifungal therapies, like amphotericin B, have serious health risks. The current study reviews the literature regarding an overview of SARS-CoV-2-associated mucormycosis, along with different terpenes from diverse edible sources such as basil, ginger, and clove, which are detected till June 2024.
View Article and Find Full Text PDFInvestigation of the Relationship Between Spousal Violence and Quality of Life Experienced by Cancer Patients Receiving Immunosuppressive Therapy.
Violence Against Women
January 2025
Gaziantep Private Medical Park Hospital, Gaziantep, Turkey.
Starting from the diagnosis stage of it and throughout the terminal period, cancer is an illness that forms serious stress for patients. The aim of this study is to investigate whether spousal violence has an effect on the quality of life of cancer patients receiving immunosuppressive therapy. This is a cross-sectional and self-reported study based on quantitative data.
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