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Screening for acute disseminated histoplasmosis in HIV disease using urinary antigen detection enzyme immunoassay: A pilot study in Cameroon.
J Microbiol Methods
June 2021
Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom; The Global Action Fund for Fungal Infections, Genève, Switzerland.
Acute disseminated histoplasmosis (ADH) is an AIDS-defining illness and reported in Cameroon, but there are few data about its incidence. Between June and August 2019, we conducted a descriptive cross-sectional study to screen for histoplasmosis in a population of adults with HIV infection, irrespective of their CD4 T-cell counts, using Histoplasma urine antigen detection enzyme immunoassay (EIA) and histoplasmin skin test. Of the 138 participants screened, 36 (26%) had detectable antigen in urine, using an OD cut off of 0.
View Article and Find Full Text PDFBurden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: a modelling study.
Lancet Infect Dis
October 2018
Centre d'Investigation Clinique 1424 Antilles-Guyane, Inserm, Centre Hospitalier de Cayenne, Cayenne, France; Equipe EA3593, Ecosystèmes Amazoniens et Pathologie Tropicale, Université de Guyane, Cayenne, France.
Background: Fungal infections remain a major contributor to the opportunistic infections that affect people living with HIV. Among them, histoplasmosis is considered neglected, often being misdiagnosed as tuberculosis, and is responsible for numerous deaths in Latin America. The objective of this study was to estimate the burden of HIV-associated histoplasmosis compared with tuberculosis in Latin American countries.
View Article and Find Full Text PDFHistoplasmosis in Africa: An emerging or a neglected disease?
PLoS Negl Trop Dis
January 2018
Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Histoplasmosis in Africa has markedly increased since the advent of the HIV/AIDS epidemic but is under-recognised. Pulmonary histoplasmosis may be misdiagnosed as tuberculosis (TB). In the last six decades (1952-2017), 470 cases of histoplasmosis have been reported.
View Article and Find Full Text PDF[Inquérito epidemiológico com paracoccidioidina e histoplasmina em área agrÃcola de café em Ibiá, Minas Gerais, Brasil.].
Rev Iberoam Micol
December 1998
Disciplina de Doenças Infecciosas e Parasitárias, Faculdade de Medicina do Triângulo Mineiro, Uberaba, Minas Gerais e Departamento de ClÃnica Médica da Faculdade de Medicina de Ribeirão Preto/USP, Ribeirâo Preto, SP, Brasil.
An epidemiological survey in an endemic area for paracoccidioidomycosis in Ibiá town, Minas Gerais state, Brazil was carried out. For this, we used a standard form for each household and intradermal antigens of histoplasmin and paracoccidioidin. Out of 194 individuals, 109(56%) were engaged in the survey showing reactivity of 44% and 49.
View Article and Find Full Text PDFHistoplasmosis infection in Spanish travelers to Latin America.
Eur J Clin Microbiol Infect Dis
December 2005
International Health Centre, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic Barcelona, c/ Villarroel 170, 08036, Barcelona, Spain.
The aim of the study presented here was to assess the incidence of histoplasma infection in a cohort of 342 individuals in Spain who had traveled to Latin America for the first time. The histoplasmin skin test was positive in 20% of the travelers, and Central America posed a higher risk for infection than South America (p=0.013).
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