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Glucose-6-Phosphatase (G6Pase), a key enzyme in gluconeogenesis and glycogenolysis in the mammalian liver and kidney, converts glucose-6-phosphate to glucose for maintaining systemic blood glucose homeostasis during nutrient deprivation. However, its function has remained elusive in insects, which have no need for G6Pase in sugar homeostasis since they convert glucose-6-phosphate to trehalose, their main circulating sugar, via trehalose phosphate synthase (TPS1). In this study we identify an unexpected and essential requirement for G6Pase in male fertility, specifically to produce motile sperm.
View Article and Find Full Text PDFThe role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs.
Physiol Rep
January 2025
Center for Translational Research in Aging and Longevity, Department of Health and Kinesiology, Texas A&M University, College Station, Texas, USA.
Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis. In a translational porcine model of sepsis, we explored the across organ net fluxes of gluconeogenic substrates.
View Article and Find Full Text PDFA paradoxical reaction after an oral glucose tolerance test revealed a pheochromocytom.
Neuro Endocrinol Lett
December 2024
Department of Internal Medicine, Tokyo Saiseikai Central Hospital, Minato-ku, Tokyo, Japan.
A 33-year-old Japanese man with a history of atopic dermatitis and asthma had never been diagnosed with any apparent glucose intolerance but had been aware of palpitations for >10 years. A 75g oral glucose tolerance test (OGTT) at his physical examination in March 2021 revealed fasting hyperglycemia and post-load hypoglycemia. An OGTT recheck was performed in May 2021 and was normal.
View Article and Find Full Text PDFSPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis.
Cell Rep
December 2024
Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address:
SPTLC3, an inducible subunit of the serine palmitoyltransferase (SPT) complex, causes production of alternative sphingoid bases, including a 16-carbon dihydrosphingosine, whose biological function is only beginning to emerge. High-fat feeding induced SPTLC3 in the liver, prompting us to produce a liver-specific knockout mouse line. Following high-fat feeding, knockout mice showed decreased fasting blood glucose, and knockout primary hepatocytes showed suppressed glucose production, a core function of hepatocytes.
View Article and Find Full Text PDFAlpha-Taxilin: A Potential Diagnosis and Therapeutics Target in Rheumatoid Arthritis Which Interacts with Key Glycolytic Enzymes Associated with Metabolic Shifts in Fibroblast-Like Synoviocytes.
J Inflamm Res
November 2024
Council of Scientific & Industrial Research (CSIR), Institute of Genomics and Integrative Biology, Delhi University Campus, Delhi, 110007, India.
Article Synopsis
- Rheumatoid Arthritis (RA) is a chronic autoimmune disease, and previous research highlighted α-Taxilin as a key protein elevated in RA, necessitating further exploration of its role in the disease.
- In a study involving 106 RA patients, α-Taxilin levels were significantly higher compared to those with osteoarthritis, systemic lupus erythematosus, and healthy individuals, and it correlated with RA severity markers.
- The study identified 17 proteins interacting with α-Taxilin, suggesting its involvement in key metabolic pathways, and experiments showed that reducing α-Taxilin levels lowered inflammation and improved symptoms in both cell cultures and a rat model of arthritis.
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