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Integrative physiological, biochemical, and proteomic analysis of the leaves of two cotton genotypes under heat stress.
PLoS One
January 2025
Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan.
Cotton (Gossypium hirsutum L.), a crucial global fibre and oil seed crop faces diverse biotic and abiotic stresses. Among these, temperature stress strongly influences its growth, prompting adaptive physiological, biochemical, and molecular changes.
View Article and Find Full Text PDFConstruction and validation of a predictive model for allergic rhinitis complicating children with bronchial asthma.
Allergol Immunopathol (Madr)
January 2025
Department of Pediatric Respiratory Medicine, Anhui Provincial Children's Hospital, Hefei City, Anhui Province, China.
This study aimed to investigate the factors influencing the complication of allergic rhinitis in children with bronchial asthma and to construct a nomogram model to predict the occurrence of allergic rhinitis. A total of 190 children with bronchial asthma admitted to our hospital from August 2020 to August 2024 were retrospectively analyzed. The children were randomly divided into the training cohort (133 cases) and validation cohort (57 cases) in a ratio of 7:3.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
University of Fribourg, Adolphe Merkle Institute, Fribourg, Switzerland.
Background: Tau protein phosphorylation and aggregation are the pathological hallmarks of Alzheimer's disease (AD) and other tauopathies. Multiple phosphorylation sites in Tau protein at serine (S), threonine (T), and tyrosine result in high heterogeneity and enhanced aggregation kinetics.
Method: Here, we used nanopores coated with a fluid lipid bilayer to characterize native and hyperphosphorylated Tau proteins on a single-molecule level.
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Alzheimers Dement
December 2024
Edith Cowan University, Joondalup, Australia; Australian E-Health Research Centre, CSIRO, Perth, Western Australia, Australia.
Background: A growing body of research has confirmed the presence of epigenetic alterations in Alzheimer's disease (AD). While the causal relationship between these changes and AD remains uncertain, they offer a novel avenue to explore potential treatments. In this study, we aimed at characterising the methylation signatures of amyloid beta (Aβ) deposition, one of the main hallmarks of AD.
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Alzheimers Dement
December 2024
Centre de recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC, Canada.
Background: Our objective was to assess individual and joint relationships between various mesoscale indicators of brain health (e.g., neuronal, metabolic, and vascular integrity) and cognitive function.
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