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Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance.
Mol Oncol
November 2024
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, China.
Gut microbiota has a proven link with the development and treatment of cancer. However, the causality between gut microbiota and cancer development is still unknown and deserves exploration. In this study, we aimed to explore the alterations in gut microbiota in murine tumor models and the crosstalk between the tumor and the gut microbiota.
View Article and Find Full Text PDFComprehensive Coverage of Glycolysis and Pentose Phosphate Metabolic Pathways by Isomer-Selective Accurate Targeted Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry Assay.
Anal Chem
October 2024
Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
The accurate liquid chromatography-tandem mass spectrometry analysis of phosphorylated isomers from glycolysis and pentose phosphate pathways is a challenging analytical problem in metabolomics due to extraction problems from the biological matrix, adherence to stainless steel surfaces leading to tailing in LC, and incomplete separation of hexose and pentose phosphate isomers. In this study, we present a targeted HILIC-ESI-MS/MS method based on a BEH amide fully porous 1.7 μm particle column with an inert surface coating of column hardware and multiple reaction monitoring (MRM) acquisition fully covering the glycolysis and pentose phosphate pathway metabolites.
View Article and Find Full Text PDFThe metagenomic landscape of a high-altitude geothermal spring in Tajikistan reveals a novel Desulfurococcaceae member, Zestomicrobium tamdykulense gen. nov., sp. nov.
Microbiologyopen
October 2024
Department of Biological Sciences, University of Bergen, Bergen, Norway.
Article Synopsis
- - A metagenomic study of the Tamdykul geothermal spring in Tajikistan discovered six major bacteria families, primarily from Thermaceae, Aquificaceae, and Halothiobacillaceae, which made up a significant portion of the microbial community.
- - The analysis identified a new metagenome-assembled genome (MAG002) belonging to the Desulfurococcaceae family, revealing a unique organism with partial DNA similarities that suggest it represents a new species and genus, named Zestomicrobium tamdykulense.
- - The MAG002 genome, which is thermophilic and includes key metabolic pathways, particularly for gluconeogenesis, was found to feature a large intron and multiple enzymes that
Electron transport chain inhibition increases cellular dependence on purine transport and salvage.
Cell Metab
July 2024
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:
Mitochondria house many metabolic pathways required for homeostasis and growth. To explore how human cells respond to mitochondrial dysfunction, we performed metabolomics in fibroblasts from patients with various mitochondrial disorders and cancer cells with electron transport chain (ETC) blockade. These analyses revealed extensive perturbations in purine metabolism, and stable isotope tracing demonstrated that ETC defects suppress de novo purine synthesis while enhancing purine salvage.
View Article and Find Full Text PDFAssociations between plasma metabolites and heavy metal exposure in residents of environmentally polluted areas.
Environ Int
May 2024
Biomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, South Korea; Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, Seoul, South Korea; Department of Digital Medicine, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:
Heavy metals are commonly released into the environment through industrial processes such as mining and refining. The rapid industrialization that occurred in South Korea during the 1960s and 1970s contributed significantly to the economy of the country; however, the associated mining and refining led to considerable environmental pollution, and although mining is now in decline in South Korea, the detrimental effects on residents inhabiting the surrounding areas remain. The bioaccumulation of toxic heavy metals leads to metabolic alterations in human homeostasis, with disruptions in this balance leading to various health issues.
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