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High-throughput label-free measurements of the optical and mechanical properties of single microparticles play an important role in biological research, drug development, and related large population assays. However, mechanical detection techniques that rely on the density contrast of a particle with respect to its environment cannot sense neutrally bouyant particles. On the other hand, neutrally buoyant particles may still have a high compressibility contrast with respect to their environment, opening a new window to their detection and analysis.
View Article and Find Full Text PDFDevelopment of mucoadhesive floating hollow beads of acyclovir with gastroretentive properties.
Pharm Dev Technol
August 2014
School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland , New Zealand.
This study aimed at improving the oral bioavailability of acyclovir (ACV) through incorporating it into gastroretentive dosage form based on floating hollow chitosan beads. Hollow chitosan beads were prepared using a solvent free, ionotropic gelation method. The effect of formulation parameters, including chitosan molecular weight and drug concentration, on bead characteristics was studied.
View Article and Find Full Text PDFTurbulent transport of material particles: an experimental study of finite size effects.
Phys Rev Lett
November 2007
Laboratoire des Ecoulements Géophysiques et Industriels, CNRS/UJF/INPG UMR5519, BP53, 38041 Grenoble, France.
We present experimental Lagrangian statistics of finite sized, neutrally bouyant, particles transported in an isotropic turbulent flow. The particle's diameter is varied over turbulent inertial scales. Finite size effects are shown not to be trivially related to velocity intermittency.
View Article and Find Full Text PDFThe phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly.
EMBO J
February 2004
Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, Copenhagen, Denmark.
The superoxide-producing phagocyte NADPH oxidase consists of a membrane-bound flavocytochrome b558 complex, and cytosolic factors p47phox, p67phox and the small GTPase Rac, which translocate to the membrane to assemble the active complex following cell activation. We here show that insolubility of NADPH oxidase subunits in nonionic detergents TX-100, Brij-58, and Brij-98 is a consequence of inclusion into cholesterol-enriched membrane microdomains (lipid rafts). Thus, flavocytochrome b558, in a cholesterol-dependent manner, segregated to the bouyant low-density detergent-resistant membrane (DRM) fraction, and the cytosolic NADPH oxidase factors associated dynamically with low-density DRM.
View Article and Find Full Text PDFGrowth phase-coupled alterations in cell structure and function of Escherichia coli.
J Bacteriol
February 2003
Division of Molecular Biology, Nippon Institute for Biological Science, Ome, Tokyo 198-0024, Japan.
Escherichia coli cultures can be fractionated into more than 20 cell populations, each having a different bouyant density and apparently representing a specific stage of cell differentiation from exponential growth to stationary phase (H. Makinoshima, A. Nishimura, and A.
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