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Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (TOFFFY) in Singapore.
BMJ Open
January 2025
Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore
Introduction: Despite the global prevalence of low fertility rates, male contributions to fertility and reproductive health outcomes have been understudied. This study aims to investigate the male contribution to fertility and explore the underlying biological mechanisms. Specifically, we aim to (1) identify male factors associated with successful pregnancy, (2) develop a fertility index incorporating modifiable factors for both males and females to predict pregnancy rate and (3) explore the relationship of male modifiable factors with semen parameters and molecular characteristics.
View Article and Find Full Text PDFHigh-Intensity End-of-Life Care Among Young and Middle-Aged Hispanic Adults With Cancer in Puerto Rico.
Med Care
January 2025
Division of Cancer Control and Population Sciences, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR.
Background: Timely palliative and hospice care, along with advanced care planning, can reduce avoidable high-intensity care and improve quality of life at the end of life (EoL).
Objective: We examined patterns of care at EoL and evaluated predictors of high-intensity care at EoL among adults aged 18-64 with cancer.
Methods: Using data from the Puerto Rico Central Cancer Registry-Health Insurance Linkage Database, we examined 1359 patients diagnosed with cancer in 2010-2019, who died of cancer between 2017 and 2019 at 64 years and younger, and who were enrolled in Medicaid or private health insurance in last 30 days before death.
Anthropometric Study of Auricular Development in Human Fetal Cadavers.
J Craniofac Surg
November 2024
Department of Computer Technology and Information Systems, Erdemli School of Applied Technology and Management, Mersin University, Mersin, Turkey.
The aim of the study is to comprehensively examine the composition and localization of the auricle in formalin-fixed human fetuses during the second and third trimesters of the antenatal period. Ninety-seven auricles were evaluated (33 females and 31 males in the second, and 22 females and 11 males in the third trimester). Nine morphometric dimensions were directly measured from auricles.
View Article and Find Full Text PDFAlterations in Gut Microbiome-Host Relationships After Immune Perturbation in Patients With Multiple Sclerosis.
Neurol Neuroimmunol Neuroinflamm
March 2025
Yale School of Medicine Department of Neurology, New Haven, CT.
Background And Objectives: Gut microbial symbionts have been shown to influence the development of autoimmunity in multiple sclerosis (MS). Emerging research points to an important relationship between the microbial-IgA interface and MS pathophysiology. IgA-secreting B cells are observed in the MS brain, and shifts in gut bacteria-IgA binding have been described in some patients with MS.
View Article and Find Full Text PDFProton Transfer Equilibrium in Pseudoprotic Ionic Liquids: Inferences on Ionic Populations.
J Phys Chem B
January 2025
Department of Chemistry and Biochemistry, Brooklyn College of the City University of New York, 2900 Bedford Ave., Brooklyn, New York 11210, United States.
Nonstoichiometric pseudoprotic ionic liquids (NPPILs) are an emerging class of ionic liquids with interesting physical properties and intriguing prospects for technological applications. However, fundamental questions remain about the proton transfer equilibria that underlie their ionic character. We use a combination of nuclear magnetic resonance spectroscopy, infrared spectroscopy, and small-angle X-ray scattering to characterize the equilibria of trihexylamine/butyric acid and water/butyric acid mixtures.
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