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Canagliflozin prevents acute kidney Injury in euglycemics rats.
Am J Physiol Renal Physiol
March 2025
Laboratory of Experimental Animal Models (Lema), Department of Medical-Surgical Nursing, School of Nursing, University of Sao Paulo, São Paulo, Brazil.
The aim of this study was to investigate the impact of canagliflozin on AKI caused by ischemia-reperfusion injury (IRI) in non-diabetic rats. Male Wistar rats weighing 250-300g were randomized into four groups: SHAM (rats subjected to sham renal ischemia-reperfusion surgery); CANA (canagliflozin by gavage, 200mg/kg, once, daily, 5 days); I/R: rats subjected to I/R- AKI (bilateral renal hilum clamping, 30 minutes); CANA+I/R: I/R rats that received canagliflozin 5 days prior to I/R. Evaluated parameters: renal function (serum creatinine [CrS], inulin clearance [inCl]; renal hemodynamics (mean arterial pressure [MAP], renal blood flow [RBF], renal vascular resistance [RVR]); redox profile (urinary peroxides, lipid peroxidation, urinary nitrate, renal tissue thiols and nuclear factor erythroid 2-related factor 2 [Nrf2] protein expression), western blot for identification of SGLT2 in the kidneys and renal histology.
View Article and Find Full Text PDFSafe Administration of Immunosuppression in Japanese Monkeys: Relevance to Preclinical Xenotransplantation Studies.
Cell Transplant
March 2025
Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
The Japanese monkey has been used in several animal studies; however, its potential as a recipient model for xenotransplantation is unclear. The potential of the Japanese monkey as a recipient for xenotransplantation was assessed using two experimental models. The first model evaluated the optimal dose of tacrolimus without severe adverse events.
View Article and Find Full Text PDFEnteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits Salmonella.
J Exp Med
June 2025
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.
To distinguish pathogens from commensals, the intestinal epithelium employs cytosolic innate immune sensors. Activation of the NAIP-NLRC4 inflammasome initiates extrusion of infected intestinal epithelial cells (IEC) upon cytosolic bacterial sensing. We previously reported that activation of the inflammasome in tuft cells, which are primarily known for their role in parasitic infections, leads to the release of prostaglandin D2 (PGD2).
View Article and Find Full Text PDFCross-Frequency Couplings Reveal Mice Visual Cortex Selectivity to Grating Orientations.
Brain Behav
March 2025
Neuroscience & Neuroengineering Research Lab., Biomedical Engineering Department, School of Electrical Engineering, Iran University of Science & Technology, Tehran, Iran.
Introduction: Oriented grating is usually employed in visual science experiments as a prominent property of neurons in the visual cortices. Previous studies have shown that the study of mouse vision can make a significant contribution to the field of neuroscience research, and also the local field potential (LFP) analysis could contain more information and give us a better view of brain function.
Methods: In this research, cross-frequency coupling is employed to assess the grating orientation perception in V1 and lateromedial (LM) of 10 mice.
Rodent surgeries: who is performing them and how?
Lab Anim
March 2025
Zurich Integrative Rodent Physiology (ZIRP), Institute of Physiology, University of Zurich, Zurich, Switzerland.
Surgery is an integral part of many experimental studies. Good surgical practice is a prerequisite for surgical success, optimal animal welfare, and it not only improves post-operative recovery but also the overall outcome and validity of a study. Rodents, especially mice, are the most commonly used laboratory animals and the legal requirements to perform experimental surgery are identical for all species.
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