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Background: Hemoglobin (HGB) is a pigment protein found in human red blood cells. Laboratories usually measure hemoglobin using a colorimetric method. The factor that causes the increase of blood turbidity (hypertri-glyceridemia) can lead to the false increase of HGB, and also cause a significant increase of MCH and MCHC.

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We have studied 32 kindreds identified by propositi with primary type V hyperlipoproteinemia. The clinical presentation, metabolic associations, and natural history confirm the distinctiveness of primary type V hyperlipoproteinemia from other lipoprotein abnormalities. Although the underlying defect(s) remains unknown, several factors such as obesity, alcohol, drugs, and diet are able to modify the glyceridemia, the major manifestation of this disorder.

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