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TPepRet: a deep learning model for characterizing T cell receptors-antigen binding patterns.
Bioinformatics
January 2025
School of Computer Science and engineering, Central South University, Changsha, 410083, China.
Motivation: T-cell receptors (TCRs) elicit and mediate the adaptive immune response by recognizing antigenic peptides, a process pivotal for cancer immunotherapy, vaccine design, and autoimmune disease management. Understanding the intricate binding patterns between TCRs and peptides is critical for advancing these clinical applications. While several computational tools have been developed, they neglect the directional semantics inherent in sequence data, which are essential for accurately characterizing TCR-peptide interactions.
View Article and Find Full Text PDFThe impact of buprenorphine prescriber data on geospatial access to treatment in HEALing Communities Study communities, 2022.
J Subst Use Addict Treat
January 2025
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA 02111, United States of America.
Introduction: The location of buprenorphine treatment providers in the United States is pivotal to the understanding of regional factors associated with prescription and uptake. We evaluated how distinct data sources of treatment providers and their associated locations contribute to the differences observed when measuring buprenorphine accessibility.
Methods: We compared buprenorphine treatment provider data from the Drug Enforcement Administration (DEA) and data from the behavioral health treatment locator from the Substance Abuse and Mental Health Services Administration (SAMHSA) for July 2022.
Constructal Thermodynamics and its Semantic Ontology in Autopoetic, Digital, and Computational Architectural and Urban Space Open Systems.
Biosystems
January 2025
ICube Laboratory, UMR 7357, Department of Mechanics, Civil Engineering and Energetics Team - GCE, CNRS, University of Strasbourg, INSA Strasbourg, Department of Architecture, 24 Boulevard de la Victoire, 67084 Strasbourg Cedex, France; MAP-Aria Laboratory, UMR CNRS/MCC 3495, École Nationale Supérieure d'Architecture de Lyon, 3 rue Maurice Audin, BP 170, 69512 Vaulx-en-Velin Cedex, France. Electronic address:
This paper explores the intersections of constructal thermodynamics, and its semantic ontology within the context of autopoetic, digital and computational design in protocell inspired numerical architectural and urban narratives that are examined here as open systems. Constructal law is the thermodynamic theory based on the analysis of fluxes across the border of an open system. Protocells, as dynamic and adaptive open finite size systems, serve in this paper as a compelling metaphor and design model for responsive and sustainable manmade architectural and urban environments.
View Article and Find Full Text PDFConstructing TheKeep.Ca With Thrivers of Cancer in Manitoba, Canada, in Support of Enhancing Patient Engagement: Protocol for a Pragmatic Multimethods Study.
JMIR Res Protoc
January 2025
College of Nursing, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Background: TheKeep.Ca was built to facilitate engagement with those experiencing cancer in Manitoba, Canada. Constructed between 2020 and 2024 with a group of patient advisors, the website includes information on engagement activities including research participation, the patient advisor role, and how those experiencing cancer can access these Manitoba activities.
View Article and Find Full Text PDFCharacterization of language abilities and semantic networks in very preterm children at school-age.
PLoS One
January 2025
Clinic of Neonatology, Department of Mother-Woman-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
It has been widely assessed that very preterm children (<32 weeks gestational age) present language and memory impairments compared with full-term children. However, differences in their underlying semantic memory structure have not been studied yet. Nevertheless, the way concepts are learned and organized across development relates to children's capacities in retrieving and using information later.
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