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Evaluation of dust and endotoxin exposure among rice mill workers in northeast India.
Toxicon
September 2024
Department of Botany, University of Lucknow, Lucknow, Uttar Pradesh, 226007, India; College of Life Science & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. Electronic address:
Exposure to particulate matter and endotoxin can lead to acute and chronic respiratory problems in workers. A study was conducted to quantify particulate matter with an aerodynamic diameter of ≤10 μm (PM10) and endotoxin levels in rice mills in northeast India. Sixty-four PM10 dust samples were collected from eight rice mills at two locations: the feeding and polishing sections for two varieties of paddy: Ranjit and Hali.
View Article and Find Full Text PDFIt is time to reconsider the use of naturally-occurring endotoxins in endotoxin recovery studies: Part 2 of a BioPhorum harmonized endotoxin recovery study.
Biologicals
August 2024
BioPhorum, The Gridiron Building, 1 Pancras Square, London, N1C 4AG, UK.
The evaluation of Naturally Occurring Endotoxins (NOEs) for Low Endotoxin Recovery (LER) studies has been a topic in the industry and regulatory agencies have been hesitant to endorse NOE use in LER studies over purified Lipopolysaccharide (LPS) standards such as Control Standard Endotoxin (CSE) or Reference Standard Endotoxin (RSE). In a recent study involving 11 BioPhorum member companies across 13 sites, NOEs prepared in high and low nutrient conditions were evaluated in two common monoclonal antibody buffer formulations: 10 mM Sodium Citrate, 0.05 % Polysorbate 80, pH 6.
View Article and Find Full Text PDFProtective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis.
Chin J Integr Med
October 2024
Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Objective: To explore the protective effect and the underlying mechanism of silibinin (SIB), one of the active compounds from Silybum marianum (L.) Gaertn in endotoxemia.
Methods: Mouse peritoneal macrophage were isolated via intraperitoneally injection of BALB/c mice with thioglycolate medium.
Detection of Beta-Glucan Contamination in Nanoparticle Formulations.
Methods Mol Biol
March 2024
Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Beta-glucans with diverse chemical structures are produced by a variety of microorganisms and are commonly found in microbial cell walls. β-(1,3)-D-glucans are present in yeast and fungi, and, for this reason, their traces are commonly used as a sign of yeast or fungal infection or contamination. Despite being less immunologically active than endotoxins, beta-glucans are pro-inflammatory and can activate cytokines and other immunological responses via their cognate pattern recognition receptors.
View Article and Find Full Text PDFDetection of endotoxins from selected drinking water microbiota using an LAL-based assay and its implications for human health.
J Water Health
February 2024
Panpharma GmbH, Bunsenstraße 4, 22946, Trittau, Germany.
Endotoxins are pyrogenic lipopolysaccharides from Gram-negative bacteria that are known to induce fever, septic shock, and multiple organ failure, posing a substantial risk to human health. Drinking water systems are especially prone to home microbiomes containing a large variety of Gram-negative bacteria. Consumption of water from these systems in developed countries is generally regarded as non-hazardous to humans due to the low number of non-pathogenic bacterial cells per milliliter and oral admission.
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