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Azithromycin removal from water via adsorption on drinking water sludge-derived materials: Kinetics and isotherms studies.
PLoS One
January 2025
Grupo de Investigación Materiales con Impacto (Mat&mpac) Universidad de Medellín, Medellín, Colombia.
In this study, we utilized drinking water treatment sludge (WTS) to produce adsorbents through the drying and calcination process. These adsorbents were then evaluated for their ability to remove azithromycin (AZT) from aqueous solutions. The L-500 adsorbent, derived from the calcination (at 500°C) of WTS generated under conditions of low turbidity in the drinking water treatment plant, presented an increase in the specific surface area from 70.
View Article and Find Full Text PDFThe Relationship between Substrate Structure and Selectivity of Ketoreduction in Multimodular Polyketide Synthases: A Comparative Study of A-Type Ketoreductases from Late Modules Using Complex Precursor Analogues.
ACS Chem Biol
January 2025
Professur Organische Chemie IV, Fakultät für Biologie, Chemie und Geowissenschaften, Department of Chemistry, Universität Bayreuth, 95447 Bayreuth, Germany.
Ketoreductases (KRs) are domains in the reductive loops of type I polyketide synthases (PKSs) and are responsible for the majority of stereocenters in reduced polyketides. Although the highly stereoselective reduction of ACP-bound β-ketothioester intermediates by KRs is crucial for the overall functioning of PKSs, the substrate-dependent stereoselectivity of KRs is a factor that is not yet fully understood, especially for KR domains in late PKS modules that act on biosynthetic precursors with complex polyketidic moieties. We present studies on the three KR domains FosKR7, PlmKR6, and EryKR6 from the biosynthetic pathways of fostriecin, phoslactomycin, and erythromycin by in vitro assays using close surrogates of the octaketidic FosKR7 biosynthetic precursor, complex derivatives and a diketide in the form of their biomimetic -acetylcysteamine thioesters.
View Article and Find Full Text PDFResidue Elimination Patterns and Determination of the Withdrawal Times of Seven Antibiotics in Eggs of Taihang Chickens.
Animals (Basel)
December 2024
College of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, China.
The objective of this study was to examine the residue elimination patterns of seven antibiotics in the eggs of Taihang chickens under free-range conditions and develop suitable withdrawal times (WDTs). A total of 240 healthy Taihang chickens, aged 180 days, were randomly divided into eight groups of 30 birds each. The first seven groups were administered oxytetracycline, chlortetracycline, erythromycin, tylosin, tylvalosin, lincomycin, and tiamulin, respectively, in accordance with the maximum dosages and longest durations of treatment recommended by the Veterinary Pharmacopoeia of the People's Republic of China.
View Article and Find Full Text PDFEffect of tropical climates on the quality of commonly used antibiotics: the protocol for a systematic review and meta-analysis.
BMJ Open
January 2025
Clinical Research Department, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Introduction: Medicine quality can be influenced by environmental factors. In low- and middle-income countries (LMICs) with tropical climates, storage facilities of medicines in healthcare settings and homes may be suboptimal. However, knowledge of the effects of temperature and other climatic and environmental factors on the quality of medicines is limited.
View Article and Find Full Text PDFGenomic epidemiology and evolution of under the vaccination pressure of acellular vaccines in Beijing, China, 2020-2023.
Emerg Microbes Infect
December 2025
Department of Immunization and Prevention, Beijing Chaoyang District Center for Disease Control and Prevention, Beijing, People's Republic of China.
Article Synopsis
- Pertussis is seeing a global increase, particularly in China post-COVID-19, despite vaccination efforts.
- A study analyzed 60 strains from Beijing from 2020-2023, revealing genetic changes and increased resistance to the antibiotic erythromycin among the isolates.
- The dominant genotype shifted significantly from those prior to 2019 due to vaccine pressure, highlighting the necessity for ongoing monitoring and updates to vaccination strategies.
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