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Sigma 1 Receptor and Its Pivotal Role in Neurological Disorders.
ACS Pharmacol Transl Sci
January 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Sigma 1 receptor (S1R) is a multifunctional, ligand-activated protein located in the membranes of the endoplasmic reticulum (ER). It mediates a variety of neurological disorders, including epilepsy, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease. The wide neuroprotective effects of S1R agonists are achieved by a variety of pro-survival and antiapoptotic S1R-mediated signaling functions.
View Article and Find Full Text PDFInsight into dipeptidase 1: structure, function, and mechanism in gastrointestinal cancer diseases.
Transl Cancer Res
December 2024
Department of Oncology, Jiangdu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Dipeptidase 1 (DPEP1), initially identified as a renal membrane enzyme in mature human kidneys, plays a pivotal role in various cellular processes. It facilitates the exchange of materials and signal transduction across cell membranes, contributing significantly to dipeptide hydrolysis, glucose and lipid metabolism, immune inflammation, and ferroptosis, among other cellular functions. Extensive research has delineated the complex role of DPEP1 in oncogenesis and tumor progression, with its influence being context dependent.
View Article and Find Full Text PDFShear-Mediated Stabilization of Spin Spiral Order in Multiferroic NiI.
Adv Mater
January 2025
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Type-II multiferroicity from non-collinear spin order is recently explored in the van der Waals material NiI. Despite the importance for improper ferroelectricity, the microscopic mechanism of the helimagnetic order remains poorly understood. Here, the magneto-structural phases of NiI are investigated using resonant magnetic X-ray scattering (RXS) and X-ray diffraction.
View Article and Find Full Text PDFAnomaly detection in multidimensional time series for water injection pump operations based on LSTMA-AE and mechanism constraints.
Sci Rep
January 2025
College of computer science and technology, China University of Petroleum (East China), No.66 Changjiang West Road, Huangdao, Qingdao, 266580, Shandong, China.
Addressing the issues of inadequate information exchange among subsequences in the operational time series of water injection pumps, leading to low accuracy and high false alarm rates in anomaly detection, this paper proposes a multidimensional time series anomaly detection method for water injection pump operations, leveraging Long Short-Term Memory Autoencoder augmented with Attention Mechanism (LSTMA-AE) and mechanistic constraints. The LSTMA-AE framework encompasses three primary modules: a Time Feature Extraction Module (Encoder), an Attention Layer, and a Data Reconstruction Module (Decoder). The Encoder captures temporal dependencies and features within the input sequences, mapping the input data into a higher-dimensional space.
View Article and Find Full Text PDFTransport and sedimentation of microplastics by turbidity currents: Dependence on suspended sediment concentration and grain size.
Environ Int
January 2025
Department of Physics, University of Girona, Campus de Montilivi, Girona 17003 Spain.
Using lock-exchange experiments, this study investigates the transport and sedimentation of microplastics (MPs) via turbidity currents. Two hypotheses were tested: MP sedimentation is influenced by suspended sediment concentration and grain size. Utilizing flows with different sediment concentrations and grain sizes in combination with three different MPs (PET fibers, melamine, and PVC fragments), the experiments revealed distinct sedimentation patterns: higher sediment concentrations enhance MP transport, and turbidity currents with finer sediments transported MPs over greater distances, highlighting the importance of sediment characteristics to predict MP distribution by such flows.
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